Promising Gene Therapeutics for Salivary Gland Radiotoxicity.

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL AIMS Medical Science Pub Date : 2016-01-01 Epub Date: 2016-11-30 DOI:10.3934/medsci.2016.4.329
Renjith Parameswaran Nair, Gulshan Sunavala-Dossabhoy
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引用次数: 6

Abstract

More than 0.5 million new cases of head and neck cancer are diagnosed worldwide each year, and approximately 75% of them are treated with radiation alone or in combination with other cancer treatments. A majority of patients treated with radiotherapy develop significant oral off-target effects because of the unavoidable irradiation of normal tissues. Salivary glands that lie within treatment fields are often irreparably damaged and a decline in function manifests as dry mouth or xerostomia. Limited ability of the salivary glands to regenerate lost acinar cells makes radiation-induced loss of function a chronic problem that affects the quality of life of the patients well beyond the completion of radiotherapy. The restoration of saliva production after irradiation has been a daunting challenge, and this review provides an overview of promising gene therapeutics that either improve the gland's ability to survive radiation insult, or alternately, restore fluid flow after radiation. The salient features and shortcomings of each approach are discussed.

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唾液腺放射毒性的有前途的基因治疗方法。
全世界每年新诊断的头颈癌病例超过50万例,其中约75%的患者接受单独放疗或与其他癌症治疗相结合的治疗。大多数接受放射治疗的患者由于不可避免的对正常组织的照射而产生明显的口服脱靶效应。位于治疗区域内的唾液腺经常受到不可修复的损伤,功能下降表现为口干或口干。唾液腺再生失去的腺泡细胞的能力有限,使得放射引起的功能丧失成为一个慢性问题,影响患者的生活质量远远超过放疗完成。放射后唾液分泌的恢复一直是一项艰巨的挑战,本文综述了一些有前途的基因治疗方法,这些基因治疗方法要么提高腺体在放射损伤中存活的能力,要么恢复放射后的体液流动。讨论了每种方法的显著特点和缺点。
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来源期刊
AIMS Medical Science
AIMS Medical Science MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
14.30%
发文量
20
审稿时长
12 weeks
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