Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial.

Q2 Medicine BMC Hematology Pub Date : 2017-03-16 eCollection Date: 2017-01-01 DOI:10.1186/s12878-017-0075-y
Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang, Amal M Saeed
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引用次数: 53

Abstract

Background: Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats. We hypothesized that regular intake of GA increases anti-oxidant capacity and reduce oxidative stress.

Methods: Forty-seven patients (5-42 years) carrying hemoglobin SS were recruited. Patients received 30 g/day GA for 12 weeks. Total anti-oxidant capacity (TAC), malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels were measured by spectrophotometric methods before and after GA intake. Complete blood count was measured by sysmex.

Results: Gum Arabic significantly increased TAC level P < 0.001and decreased the oxidative markers MDA (P < 0.05) and H2O2 (P < 0.005).

Conclusions: GA has potent anti- oxidative properties in sickle cell anemia. The anti-oxidant effect of GA may thus favorably influence the clinical condition of this and further diseases characterized by oxidative stress.

Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015. Retrospective registration.

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阿拉伯胶作为新型抗氧化剂治疗镰状细胞性贫血,II期试验。
背景:镰状细胞性贫血患者由于慢性炎症和镰状血红蛋白(Hb S)的自氧化而发生氧化应激,慢性氧化应激有助于镰状细胞病(SCD)的内皮功能障碍、炎症和多器官损伤。因此,抗氧化药物可能有利于影响疾病。阿拉伯胶(GA),可食用的,干燥的,胶状渗出物,从阿拉伯刺槐树塞内加尔,已被声称作为一种抗氧化剂和细胞保护剂,防止实验性肝,肾和心脏毒性的大鼠。我们假设经常摄入GA可以增加抗氧化能力并减少氧化应激。方法:选取47例携带血红蛋白SS的患者(5 ~ 42岁)。患者接受30 g/天GA治疗,持续12周。采用分光光度法测定GA摄入前后总抗氧化能力(TAC)、丙二醛(MDA)和过氧化氢(H2O2)水平。用sysmex检测全血细胞计数。结果:阿拉伯胶显著提高镰状细胞性贫血患者TAC水平P P 2O2 (P)。结论:GA对镰状细胞性贫血具有明显的抗氧化作用。因此,GA的抗氧化作用可能有利于影响这种疾病和其他以氧化应激为特征的疾病的临床状况。试验注册:ClinicalTrials.gov标识符:NCT02467257。2015年6月3日注册。回顾登记。
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来源期刊
BMC Hematology
BMC Hematology Medicine-Hematology
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.
期刊最新文献
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