Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach

Q2 Medicine Experimental and Toxicologic Pathology Pub Date : 2017-07-05 DOI:10.1016/j.etp.2017.02.009

Deepmala Joshi , Deepak Kumar Mittal , Sangeeta Shukla , Sunil Kumar Srivastav , Vaibhav A. Dixit

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引用次数: 32

Abstract

The present investigation has been conducted to evaluate the therapeutic potential of Curcuma longa (200 mg kg⁻¹, po) and curcumin (80 mg kg⁻¹, po) for their hepatoprotective efficacy against mercuric chloride (HgCl₂: 12 μmol kg⁻¹, ip; once only) hepatotoxicity. The HgCl₂ administration altered various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides and cholesterol contents with a concomitant decline in protein and albumin concentration in serum which were restored towards control by therapy of Curcuma longa or curcumin. On the other hand, both treatments showed a protective effect on drug metabolizing enzymes viz. aniline hydroxylase (AH) and amidopyrine-N-demethylase (AND), hexobarbitone induced sleep time and BSP retention. Choleretic, 1,1-diphenyl-2-picryl-hydrazil (DPPH)-free radical scavenging activities and histological studies also supported the biochemical findings. The present study concludes that Curcuma longa extract or curcumin has the ability to alleviate the hepatotoxic effects caused by HgCl₂ in rats.

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姜黄;提取物和姜黄素保护CYP 2E1酶活性免受氯化汞诱导的肝毒性和氧化应激:一种保护方法

本研究评价了姜黄(200 mg kg - 1, po)和姜黄素(80 mg kg - 1, po)对氯化汞(HgCl2: 12 μmol kg - 1, ip;只有一次)肝毒性。给药HgCl2可改变血清转氨酶、碱性磷酸酶、乳酸脱氢酶、胆红素、γ -谷氨酰转移酶、甘油三酯和胆固醇等生化指标，同时血清蛋白和白蛋白浓度下降，经姜黄或姜黄素治疗后恢复到控制水平。另一方面，两种处理对药物代谢酶(苯胺羟化酶(AH)和氨基比林- n -去甲基化酶(and))、六巴比妥诱导睡眠时间和BSP保留均有保护作用。胆甾体，1,1-二苯基-2-苦味酰肼(DPPH)自由基清除活性和组织学研究也支持生化研究结果。本研究认为，姜黄提取物或姜黄素具有减轻HgCl2对大鼠肝毒性的作用。

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来源期刊

Experimental and Toxicologic Pathology 医学-病理学

CiteScore

2.08

自引率

0.00%

发文量

审稿时长

5.3 weeks

期刊介绍： Cessation. The international multidisciplinary journal is devoted to the publication of studies covering the whole range of experimental research on disease processes and toxicology including cell biological investigations. Its aim is to support progress in the interdisciplinary cooperation of researchers working in pathobiology, toxicology, and cell biology independent of the methods applied. During the past decades increasing attention has been paid to the importance of toxic influence in the pathogenesis of human and animal diseases. This is why Experimental and Toxicologic Pathology meets the urgent need for an interdisciplinary journal felt by a wide variety of experts in medicine and biology, including pathologists, toxicologists, biologists, physicians, veterinary surgeons, pharmacists, and pharmacologists working in academic, industrial or clinical institutions.