Electrochemical determination of closantel in the commercial formulation by square-wave adsorptive stripping voltammetry.

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Monatshefte Fur Chemie Pub Date : 2017-01-01 Epub Date: 2016-10-28 DOI:10.1007/s00706-016-1862-z

Mariola Brycht, Agnieszka Nosal-Wiercińska, Karolina Sipa, Konrad Rudnicki, Sławomira Skrzypek

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引用次数: 11

Abstract

Abstract: In this paper, the square-wave adsorptive stripping voltammetric (SWAdSV) determination of the veterinary drug closantel using a renewable silver amalgam film electrode (Hg(Ag)FE) is presented. As observed in SWAdSV, closantel provided one well-shaped reduction peak suitable for analytical purposes at potential ca. -1.4 V in the Britton-Robinson (B-R) buffer at pH 7.0. At optimal conditions, the SWAdSV response of Hg(Ag)FE for determining closantel was linear over two concentration ranges of 5.0 × 10^-8 to 2.0 × 10^-7 mol dm^-3 and 2.0 × 10^-7 to 1.2 × 10^-6 mol dm^-3 with a detection limit of 1.1 × 10^-8 mol dm^-3. In addition, a relevance of the developed SWAdSV method was successfully verified by the quantitative analysis of closantel in the commercial formulation Closamectin Pour-On with satisfactory results (RSD = 5.8%, recovery = 101.8%). The results showed that the developed procedure can be adequate for screening purposes. Also, the electrochemical behavior of closantel was characterized by cyclic voltammetry, and it was found that closantel exhibited a quasi-reversible behavior with cathodic peak on the forward scan at ca. -1.4 V and anodic peak on the reverse scan at ca. -1.35 V vs. Ag/AgCl in B-R buffer, pH 7.0. As the obtained results showed that the electrode mechanism of closantel is controlled by the adsorption, the effect of adsorption was studied using the electrochemical impedance spectroscopy technique.

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方波吸附溶出伏安法测定商业配方中氯桑特的电化学含量。

摘要:本文采用可再生银汞合金薄膜电极(Hg(Ag)FE)，建立了方波吸附溶出伏安法(SWAdSV)测定兽药closantel的方法。在SWAdSV中观察到，closantel在pH 7.0的briton - robinson (B-R)缓冲液中提供了一个形状良好的还原峰，电位约为-1.4 V，适合于分析目的。在最佳条件下，Hg(Ag)FE在5.0 × 10-8 ~ 2.0 × 10-7 mol dm-3和2.0 × 10-7 ~ 1.2 × 10-6 mol dm-3浓度范围内呈线性响应，检出限为1.1 × 10-8 mol dm-3。此外，通过对商业配方Closamectin - on中closamtel的定量分析，验证了SWAdSV方法的相关性，结果令人满意(RSD = 5.8%，回收率= 101.8%)。结果表明，所开发的程序可以充分筛选的目的。用循环伏安法对closantel的电化学行为进行了表征，发现closantel在pH 7.0的B-R缓冲液中，在ca. -1.4 V时正扫描呈阴极峰，在ca. -1.35 V时反扫描呈阳极峰。结果表明，吸附控制了closantel的电极机理，因此采用电化学阻抗谱技术对吸附效果进行了研究。图形化的简介:

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来源期刊

Monatshefte Fur Chemie 化学-化学综合

CiteScore

3.70

自引率

5.60%

发文量

116

审稿时长

3.3 months

期刊介绍： "Monatshefte für Chemie/Chemical Monthly" was originally conceived as an Austrian journal of chemistry. It has evolved into an international journal covering all branches of chemistry. Featuring the most recent advances in research in analytical chemistry, biochemistry, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, Chemical Monthly publishes refereed original papers and a section entitled "Short Communications". Reviews, symposia in print, and issues devoted to special fields will also be considered.