Corneal Toxicity Following Exposure to Asclepias Tuberosa.

IF 0.4 Q4 OPHTHALMOLOGY Open Ophthalmology Journal Pub Date : 2017-01-31 eCollection Date: 2017-01-01 DOI:10.2174/1874364101711010001

Lauge Hjorth Mikkelsen, Hassan Hamoudi, Cigdem Altuntas Gül, Steffen Heegaard

{"title":"Corneal Toxicity Following Exposure to Asclepias Tuberosa.","authors":"Lauge Hjorth Mikkelsen, Hassan Hamoudi, Cigdem Altuntas Gül, Steffen Heegaard","doi":"10.2174/1874364101711010001","DOIUrl":null,"url":null,"abstract":"Purpose: To present a case of corneal toxicity following exposure to milky plant latex from Asclepias tuberosa.Methods: A 70-year-old female presented with blurred vision and pain in her left eye after handling an Ascepias tuberosa. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.Results: The corneal oedema had appeared after corneal exposure to the plant, Asclepias tuberosa, whose latex contains cardenolides that inhibit the Na+/ K+-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.Conclusion: Corneal toxicity has previously been reported for plants of the Asclepias family. This is a rare case describing severe corneal toxicity caused by exposure to latex from Asclepias tuberosa. Handling of plants of the Asclepias family should be kept as a differential diagnosis in cases of acute corneal toxicity.","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/5b/TOOPHTJ-11-1.PMC5362972.pdf","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Ophthalmology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874364101711010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 9

Abstract

Purpose: To present a case of corneal toxicity following exposure to milky plant latex from Asclepias tuberosa.

Methods: A 70-year-old female presented with blurred vision and pain in her left eye after handling an Ascepias tuberosa. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.

Results: The corneal oedema had appeared after corneal exposure to the plant, Asclepias tuberosa, whose latex contains cardenolides that inhibit the Na⁺/ K⁺-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.

Conclusion: Corneal toxicity has previously been reported for plants of the Asclepias family. This is a rare case describing severe corneal toxicity caused by exposure to latex from Asclepias tuberosa. Handling of plants of the Asclepias family should be kept as a differential diagnosis in cases of acute corneal toxicity.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

暴露于龙葵后的角膜毒性。

目的:报告一例接触牛膝乳汁引起的角膜毒性。方法:一位70岁的女性，在处理结节性腹肌后出现视力模糊和左眼疼痛。临床检查发现角膜间质水肿伴小的上皮缺损。角膜内皮完整，Descemets膜有皱褶。用氯霉素、地塞米松、东莨菪碱治疗水肿。结果:因其乳胶中含有可抑制角膜内皮Na+/ K+- atp酶活性的硬核内酯，导致角膜接触后出现角膜水肿。96小时后水肿消失。9个月后，最佳矫正视力为20/20。结论:以前曾报道过黄芪属植物的角膜毒性。这是一个罕见的情况下，描述严重的角膜毒性引起的乳胶暴露的橡胶树。处理Asclepias家族植物应保留作为急性角膜毒性病例的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Open Ophthalmology Journal OPHTHALMOLOGY-

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： The Open Ophthalmology Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in ophthalmology, including use of ophthalmological therapies, devices and surgical techniques. The Open Ophthalmology Journal, a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and making them freely available to researchers worldwide.