Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study.

Q2 Medicine BMC Hematology Pub Date : 2017-04-20 eCollection Date: 2017-01-01 DOI:10.1186/s12878-017-0079-7
Anne M Andong, Eveline D T Ngouadjeu, Cavin E Bekolo, Vincent S Verla, Daniel Nebongo, Yannick Mboue-Djieka, Simeon-Pierre Choukem
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引用次数: 15

Abstract

Background: Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of the global burden of SCD, there is a paucity of data on these complications and their effects on the QOL. We aimed to record these chronic complications, to estimate the QOL, and to identify the corresponding risk factors in patients with SCD receiving care in three hospitals in Cameroon.

Methods: In this cross-sectional study, a questionnaire was used to collect data from consecutive consenting patients. Information recorded included data on the yearly frequency of painful crisis, the types of SCD, and the occurrence of chronic complications. A 36-Item Short Form (SF-36) standard questionnaire that examines the level of physical and mental well-being, was administered to all eligible participants. Data were analyzed with STATA® software.

Results: Of 175 participants included, 93 (53.1%) were female and 111 (aged ≥14 years) were eligible for QOL assessment. The median (interquartile range, IQR) age at diagnosis was 4.0 (2.0-8.0) years and the median (IQR) number of yearly painful crisis was 3.0 (1.0-7.0). The most frequent chronic complications reported were: nocturnal enuresis, chronic leg ulcers, osteomyelitis and priapism (30.9%, 24.6%, 19.4%, and 18.3% respectively). The prevalence of stroke and avascular necrosis of the hip were 8.0% and 13.1% respectively. The median (IQR) physical and mental scores were 47.3 (43.9-58.5) and 41.0 (38.8-44.6) respectively. Age and chronic complications such as stroke and avascular necrosis were independently associated with poor QOL.

Conclusions: In this population of patients living with SCD, chronic complications are frequent and their QOL is consequently poor. Our results highlight the need for national guidelines for SCD control, which should include new-born screening programs and strategies to prevent chronic complications.

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喀麦隆三家医院接受治疗的镰状细胞病患者的慢性并发症和生活质量:一项横断面研究。
背景:镰状细胞病(SCD)与慢性多系统并发症有关,这些并发症严重影响患者早期的生活质量。尽管撒哈拉以南非洲承担了全球75%的SCD负担,但关于这些并发症及其对生活质量的影响的数据却很少。我们的目的是记录这些慢性并发症,评估在喀麦隆三家医院接受治疗的SCD患者的生活质量,并确定相应的风险因素。方法:在这项横断面研究中,使用问卷从连续同意的患者中收集数据。记录的信息包括每年疼痛危机的频率、SCD的类型和慢性并发症的发生率。对所有符合条件的参与者进行了一份36项简式(SF-36)标准问卷调查,该问卷调查了身心健康水平。使用STATA®软件对数据进行分析。结果:在175名参与者中,93名(53.1%)为女性,111名(年龄≥14岁)符合生活质量评估条件。诊断时的中位(四分位间距,IQR)年龄为4.0岁(2.0-8.0),年疼痛危象的中位数为3.0(1.0-7.0)。报告的最常见的慢性并发症是:夜间遗尿、慢性腿部溃疡、骨髓炎和阴茎异常勃起(分别为30.9%、24.6%、19.4%和18.3%)。脑卒中和髋关节缺血性坏死的发生率分别为8.0%和13.1%。中位(IQR)生理和心理得分分别为47.3(43.9-58.5)和41.0(38.8-44.6)。年龄和慢性并发症,如中风和缺血性坏死,与生活质量差独立相关。结论:在SCD患者中,慢性并发症很常见,因此他们的生活质量很差。我们的研究结果强调了国家SCD控制指南的必要性,其中应包括新生儿筛查计划和预防慢性并发症的策略。
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来源期刊
BMC Hematology
BMC Hematology Medicine-Hematology
CiteScore
4.10
自引率
0.00%
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0
期刊介绍: BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.
期刊最新文献
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