Reproductive toxicity of Roundup herbicide exposure in male albino rat

Q2 Medicine Experimental and Toxicologic Pathology Pub Date : 2017-09-05 DOI:10.1016/j.etp.2017.04.007

Folarin O. Owagboriaye , Gabriel A. Dedeke , Kehinde O. Ademolu , Olarenwaju O. Olujimi , Joseph S. Ashidi , Aladesida A. Adeyinka

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引用次数: 71

Abstract

The incidence of infertility in human is on the increase and the use of Roundup herbicide and presence of its residues in foodstuff is a major concern. This study therefore aim to assess the effect of Roundup on the reproductive capacity of 32 adult male albino rats randomized into 4 groups of 8 rats per group orally exposed to Roundup at 3.6 mg/kg body weight(bw), 50.4 mg/kg bw and 248.4 mg/kgbw of glyphosate concentrations for 12 weeks while the control group was given distilled water. Serum level of reproductive hormone (testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin), oxidative stress indices in the testicular tissue, epididymal sperm morphology assessment and testicular histopathology of the rats were used as a diagnostic marker of reproductive dysfunction. Significant (p < 0.05) alterations in the level of all the reproductive hormones and oxidative stress markers assayed were observed in rats exposed to Roundup. Significant reductions (p < 0.05) in sperm count, percentage motility and significant (p < 0.05) increased in abnormal sperm cells were observed in the exposed rats. Histopathologically, severe degenerative testicular architectural lesions were seen in the Roundup exposed rats. Roundup may interfere with spermatogenesis and impair fertility in male gonad.

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农达除草剂对雄性白化大鼠生殖毒性的影响

人类不孕症的发病率正在上升，农达除草剂的使用及其在食品中的残留是一个主要问题。因此，本研究旨在评估农达对32只成年雄性白化大鼠生殖能力的影响，随机分为4组，每组8只，分别以3.6 mg/kg体重(bw)、50.4 mg/kg体重(bw)和248.4 mg/kgbw的草甘膦浓度口服农达12周，对照组给予蒸馏水。以大鼠血清生殖激素(睾酮、黄体生成素、促卵泡激素、催乳素)水平、睾丸组织氧化应激指标、附睾精子形态评价和睾丸组织病理学作为生殖功能障碍的诊断指标。显著性(p <在农达暴露大鼠中，观察到所有生殖激素和氧化应激标志物水平的变化(0.05)。显著减少(p <0.05)，且显著(p <(0.05)，异常精子细胞增多。在组织病理学上，暴露于农达的大鼠可见严重的退行性睾丸结构病变。农达可能干扰精子发生，损害男性性腺的生育能力。

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来源期刊

Experimental and Toxicologic Pathology 医学-病理学

CiteScore

2.08

自引率

0.00%

发文量

审稿时长

5.3 weeks

期刊介绍： Cessation. The international multidisciplinary journal is devoted to the publication of studies covering the whole range of experimental research on disease processes and toxicology including cell biological investigations. Its aim is to support progress in the interdisciplinary cooperation of researchers working in pathobiology, toxicology, and cell biology independent of the methods applied. During the past decades increasing attention has been paid to the importance of toxic influence in the pathogenesis of human and animal diseases. This is why Experimental and Toxicologic Pathology meets the urgent need for an interdisciplinary journal felt by a wide variety of experts in medicine and biology, including pathologists, toxicologists, biologists, physicians, veterinary surgeons, pharmacists, and pharmacologists working in academic, industrial or clinical institutions.