Moving-horizon-like state estimation via continuous glucose monitor feedback in MPC of an artificial pancreas for type 1 diabetes.

Abstract

An extension of a novel state estimation scheme is presented. The proposed method is developed for model predictive control (MPC) of an artificial pancreas for automatic insulin delivery to people with type 1 diabetes mellitus; specifically, glycemia control based on feedback by a continuous glucose monitor. The state estimation strategy is akin to moving-horizon estimation, but effectively exploits knowledge of sensor recalibrations, ameliorates the effects of delays between measurements and the controller call, and accommodates irregularly sampled output measurements. The method performs a function fit and a sampling action to synthesize a mock output trajectory for constructing the state. In this paper the structure of the fitted function prototype is divorced from the structure of the function that is sampled, facilitating the strategic elimination of prediction artifacts that are not observed in the actual plant. The proposed estimation strategy is demonstrated using clinical data collected by a Dexcom G4 Platinum continuous glucose monitor.