{"title":"ANTI-VIRAL EFFECT OF HERBAL MEDICINE KOREAN TRADITIONAL <i>CYNANCHUM PANICULATUM</i> (BGE.) KITAG EXTRACTS.","authors":"Woong Kim, Tae-Seok Oh, Youn-Jin Park","doi":"10.21010/ajtcam.v14i3.21","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pestiviruses in general, and Bovine Viral Diarrhea (BVD) in particular, present several potential targets for directed antiviral therapy.</p><p><strong>Material and methods: </strong>The antiviral effect of <i>Cynanchum paniculatum</i> (Bge.) Kitag (Dog strangling vine: DS) extract on the bovine viral diarrhea (BVD) virus was tested. First, a cytotoxicity test in MDBK (Madin-Darby bovine kidney) cells was done with all organic extract concentrations.</p><p><strong>Results: </strong>The cytotoxic concentration CC<sub>50</sub> for the ethyl acetate (EA) extracts was 18.2 ug/ml. In the tissue culture, infectious dose (TCID<sub>50</sub>) assay, the BVD virus decreased when treated with 18.2 ug/ml of the ethyl acetate extracts.</p><p><strong>Conclusion: </strong>Ethyl acetate extracts and fractions of the DS extract could be used as a potential antiviral for BVD.</p>","PeriodicalId":7845,"journal":{"name":"African journal of traditional, complementary, and alternative medicines : AJTCAM","volume":"14 3","pages":"194-198"},"PeriodicalIF":0.0000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21010/ajtcam.v14i3.21","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"African journal of traditional, complementary, and alternative medicines : AJTCAM","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21010/ajtcam.v14i3.21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Background: Pestiviruses in general, and Bovine Viral Diarrhea (BVD) in particular, present several potential targets for directed antiviral therapy.
Material and methods: The antiviral effect of Cynanchum paniculatum (Bge.) Kitag (Dog strangling vine: DS) extract on the bovine viral diarrhea (BVD) virus was tested. First, a cytotoxicity test in MDBK (Madin-Darby bovine kidney) cells was done with all organic extract concentrations.
Results: The cytotoxic concentration CC50 for the ethyl acetate (EA) extracts was 18.2 ug/ml. In the tissue culture, infectious dose (TCID50) assay, the BVD virus decreased when treated with 18.2 ug/ml of the ethyl acetate extracts.
Conclusion: Ethyl acetate extracts and fractions of the DS extract could be used as a potential antiviral for BVD.
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