Metal Resistance and Its Association With Antibiotic Resistance.

2区生物学 Q1 Biochemistry, Genetics and Molecular Biology Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-04-03 DOI:10.1016/bs.ampbs.2017.02.001

Chandan Pal, Karishma Asiani, Sankalp Arya, Christopher Rensing, Dov J Stekel, D G Joakim Larsson, Jon L Hobman

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引用次数: 231

Abstract

Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development of antibiotic resistance is considered to be the use, misuse and overuse of antibiotics in humans and animals. Nonantibiotic compounds, such as antibacterial biocides and metals, may also contribute to the promotion of antibiotic resistance through co-selection. This may occur when resistance genes to both antibiotics and metals/biocides are co-located together in the same cell (co-resistance), or a single resistance mechanism (e.g. an efflux pump) confers resistance to both antibiotics and biocides/metals (cross-resistance), leading to co-selection of bacterial strains, or mobile genetic elements that they carry. Here, we review antimicrobial metal resistance in the context of the antibiotic resistance problem, discuss co-selection, and highlight critical knowledge gaps in our understanding.

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金属耐药性及其与抗生素耐药性的关系。

抗生素耐药性被世界卫生组织认定为对公共卫生的主要全球威胁。目前，每年有数十万人死于耐抗生素细菌感染。抗生素耐药性发展的主要驱动因素被认为是在人类和动物中使用、误用和过度使用抗生素。非抗生素化合物，如抗菌杀菌剂和金属，也可能通过共选择促进抗生素耐药性。当抗生素和金属/杀菌剂的耐药基因在同一细胞中共存(共耐药)，或单一耐药机制(如外排泵)同时对抗生素和杀菌剂/金属产生耐药性(交叉耐药)，导致细菌菌株或它们携带的可移动遗传元件的共同选择时，就可能发生这种情况。在这里，我们回顾了抗生素耐药性问题背景下的抗微生物金属耐药性，讨论了共同选择，并强调了我们理解中的关键知识空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Microbial Physiology 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

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期刊介绍： Advances in Microbial Physiology publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, the editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to traditional views of whole cell physiology.

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