MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease.

Nephron Extra Pub Date : 2017-04-07 eCollection Date: 2017-01-01 DOI:10.1159/000458711

Dag Eckersten, Christos Tsatsanis, Aleksander Giwercman, Laila Bruun, Mats Pihlsgård, Anders Christensson

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引用次数: 10

Abstract

Background/aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility.

Methods: Thirty male patients with CKD 1-4 as well as 18 healthy controls were enrolled.

Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1-2 (4.51 ± 3.81 [p = 0.01]) and stages 3-4 (2.75 ± 1.77 [p = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3-4 (42 ± 29) ×10⁶/mL compared to controls (88 ± 42) ×10⁶/mL (p = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (p = 0.02) and with a low total sperm number (p = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (p = 0.02).

Conclusions: We conclude that men with stage 3-4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1-4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.

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MicroRNA-155和抗勒氏激素:慢性肾脏疾病男性生育能力低下的新潜在标志物

背景/目的:终末期肾功能衰竭的男性往往不育。抗勒氏激素(AMH)，一种支持细胞功能的标志物，在患有慢性肾脏疾病(CKD)的男性中下降。最近，一种名为miR-155的microRNA被证明是低生育能力的潜在标记物。我们研究了未进行透析的CKD患者的miR-155和精液参数。我们还旨在研究AMH、miR-155和精液参数之间的可能关联，以评估它们作为生育指标的价值。方法:30例男性CKD 1-4患者和18例健康对照。结果:1-2期CKD患者血清miR-155水平(4.51±3.81 [p = 0.01])和3-4期患者血清miR-155水平(2.75±1.77 [p = 0.006])明显高于对照组(1.09±0.44)。CKD 3-4患者的精子浓度(42±29)×106/mL明显低于对照组(88±42)×106/mL (p = 0.011)。高水平的miR-155与相对较低的精子浓度(p = 0.02)和较低的精子总数(p = 0.005)相关。低AMH水平与活动精子细胞百分比下降相关(p = 0.02)。结论:我们得出结论，3-4期CKD男性的精子浓度低于健康的有生育能力的男性，并且1-4期CKD男性血清miR-155的升高与表明低生育能力的精液参数相关。低AMH水平与活跃精子总数的低百分比有关。miR-155和AMH可能是CKD男性生育能力低下的潜在标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephron Extra

自引率

0.00%

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审稿时长

12 weeks

期刊介绍： An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.