Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases.

Q1 Biochemistry, Genetics and Molecular Biology Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2017-09-01 Epub Date: 2017-05-31 DOI:10.1002/wdev.279

Yeojin Lee, Matthew Decker, Heather Lee, Lei Ding

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引用次数: 18

Abstract

Lifelong generation of blood and immune cells depends on hematopoietic stem cells (HSCs). Their function is precisely regulated by complex molecular networks that integrate and respond to ever changing physiological demands of the body. Over the past several years, significant advances have been made in understanding the extrinsic regulation of HSCs during development and in homeostasis. Propelled by technical advances in the field, the cellular and molecular components of the microenvironment that support HSCs in vivo are emerging. In addition, the interaction of HSCs with their niches is appreciated as a critical contributor to the pathogenesis of a number of hematologic disorders. Here, we review these advances in detail and highlight the extrinsic regulation of HSCs in the context of development, homeostasis, and diseases. WIREs Dev Biol 2017, 6:e279. doi: 10.1002/wdev.279 For further resources related to this article, please visit the WIREs website.

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造血干细胞在发育、体内平衡和疾病中的外在调节。

血液和免疫细胞的终身生成依赖于造血干细胞(hsc)。它们的功能是由复杂的分子网络精确调节的，这些网络整合并响应身体不断变化的生理需求。在过去的几年中，在理解造血干细胞在发育和稳态过程中的外在调控方面取得了重大进展。在该领域技术进步的推动下，体内支持造血干细胞的微环境的细胞和分子成分正在出现。此外，造血干细胞与其生态位的相互作用被认为是许多血液病发病机制的关键因素。在这里，我们详细回顾了这些进展，并强调了造血干细胞在发育、体内平衡和疾病背景下的外在调节。中国生物医学工程学报，2017,26(6):779 - 779。doi: 10.1002 / wdev.279有关与本文相关的更多资源，请访问WIREs网站。

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Wiley Interdisciplinary Reviews: Developmental Biology DEVELOPMENTAL BIOLOGY-

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期刊介绍： Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.