Stem cells and stroke-how glowing neurons illuminate new paths.

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-16 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1304847
Dinko Mitrečić, Ivan Alić, Dunja Gorup
{"title":"Stem cells and stroke-how glowing neurons illuminate new paths.","authors":"Dinko Mitrečić,&nbsp;Ivan Alić,&nbsp;Dunja Gorup","doi":"10.1080/23262133.2017.1304847","DOIUrl":null,"url":null,"abstract":"<p><p>A reliable method of cell tracing is essential in evaluating potential therapeutic procedures based on stem cell transplantation. Here we present data collected using neural stem cells isolated from a transgenic mouse line Thy1-YFP. When transplanted into a stroke affected brain these cells give rise to neurons that express a fluorescent signal which can be used for their detection and tracing. Observed processes were compared with those taking place during normal embryonic neurogenesis as well as during <i>in vitro</i> differentiation. Since the same neurogenic patterns were observed, we confirm that neural stem cell transplantation fits well into the paradigm of neuronal birth and differentiation.</p>","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1304847","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurogenesis (Austin, Tex.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23262133.2017.1304847","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

Abstract

A reliable method of cell tracing is essential in evaluating potential therapeutic procedures based on stem cell transplantation. Here we present data collected using neural stem cells isolated from a transgenic mouse line Thy1-YFP. When transplanted into a stroke affected brain these cells give rise to neurons that express a fluorescent signal which can be used for their detection and tracing. Observed processes were compared with those taking place during normal embryonic neurogenesis as well as during in vitro differentiation. Since the same neurogenic patterns were observed, we confirm that neural stem cell transplantation fits well into the paradigm of neuronal birth and differentiation.

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
干细胞和中风——发光的神经元如何照亮新的道路。
一种可靠的细胞追踪方法对于评估基于干细胞移植的潜在治疗方法至关重要。在这里,我们展示了从转基因小鼠系Thy1-YFP中分离的神经干细胞收集的数据。当这些细胞被移植到中风患者的大脑中时,就会产生神经元,这些神经元会表达一种荧光信号,这种荧光信号可以用来检测和追踪中风患者。将观察到的过程与正常胚胎神经发生和体外分化过程中发生的过程进行比较。由于观察到相同的神经发生模式,我们证实神经干细胞移植很好地符合神经元出生和分化的范式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Role of neoblasts in the patterned postembryonic growth of the platyhelminth Macrostomum lignano. There's no place like home - HGF-c-MET signaling and melanocyte migration into the mammalian cochlea Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives. Opportunities lost and gained: Changes in progenitor competence during nervous system development. Endogenous Brain Repair: Overriding intrinsic lineage determinates through injury-induced micro-environmental signals.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1