Stem cells and stroke-how glowing neurons illuminate new paths.

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-16 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1304847
Dinko Mitrečić, Ivan Alić, Dunja Gorup
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引用次数: 3

Abstract

A reliable method of cell tracing is essential in evaluating potential therapeutic procedures based on stem cell transplantation. Here we present data collected using neural stem cells isolated from a transgenic mouse line Thy1-YFP. When transplanted into a stroke affected brain these cells give rise to neurons that express a fluorescent signal which can be used for their detection and tracing. Observed processes were compared with those taking place during normal embryonic neurogenesis as well as during in vitro differentiation. Since the same neurogenic patterns were observed, we confirm that neural stem cell transplantation fits well into the paradigm of neuronal birth and differentiation.

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干细胞和中风——发光的神经元如何照亮新的道路。
一种可靠的细胞追踪方法对于评估基于干细胞移植的潜在治疗方法至关重要。在这里,我们展示了从转基因小鼠系Thy1-YFP中分离的神经干细胞收集的数据。当这些细胞被移植到中风患者的大脑中时,就会产生神经元,这些神经元会表达一种荧光信号,这种荧光信号可以用来检测和追踪中风患者。将观察到的过程与正常胚胎神经发生和体外分化过程中发生的过程进行比较。由于观察到相同的神经发生模式,我们证实神经干细胞移植很好地符合神经元出生和分化的范式。
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