A study on role of triiodothyronine (T3) hormone on the improvement of articular cartilage surface architecture

Q2 Medicine Experimental and Toxicologic Pathology Pub Date : 2017-10-02 DOI:10.1016/j.etp.2017.05.010

Pei-tong Jia , Xing-lin Zhang , Hai-ning Zuo , Xing Lu , Peng-zhou Gai

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引用次数: 5

Abstract

The present study was aimed to investigate the effect of triiodothyronine (T3) on the improvement of articular cartilage surface architecture at in vitro level. The T3 hormone was applied to neo-tissues in the range of 50, 100, 150 and 200 ng/ml for 5 weeks. At the end of the treatment, biochemical and histological evaluation was carried out in the neo-tissues. T3 hormone application significantly increased the collagen production in neo-cartilage tissues. The properties of tensile and compressive were significantly increased compared to the controls. However, T3 hormone application also induced hypertrophy. At the higher dose concentration of T3 hormone application, tensile and compressive properties were tremendously increased 4.3 and 4.6 fold respectively. Taking all these data together, it suggested that the T3 hormone application could be a potential agent to increase the functional properties such tensile and compressive in neo-tissues.

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三碘甲状腺原氨酸(T3)激素对关节软骨表面结构改善作用的研究

本研究旨在探讨三碘甲状腺原氨酸(T3)在体外水平对关节软骨表面结构的改善作用。T3激素在50、100、150和200 ng/ml范围内作用于新生组织5周。治疗结束后，对新生组织进行生化和组织学评价。T3激素的应用显著增加了新生软骨组织中胶原蛋白的产生。与对照组相比，拉伸和压缩性能显着增加。然而，使用T3激素也会引起肥厚。在较高剂量浓度的T3激素应用下，拉伸和压缩性能分别显著提高4.3倍和4.6倍。综上所述，提示T3激素的应用可能是一种潜在的药物，可以增加新组织的拉伸和压缩等功能特性。

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来源期刊

Experimental and Toxicologic Pathology 医学-病理学

CiteScore

2.08

自引率

0.00%

发文量

审稿时长

5.3 weeks

期刊介绍： Cessation. The international multidisciplinary journal is devoted to the publication of studies covering the whole range of experimental research on disease processes and toxicology including cell biological investigations. Its aim is to support progress in the interdisciplinary cooperation of researchers working in pathobiology, toxicology, and cell biology independent of the methods applied. During the past decades increasing attention has been paid to the importance of toxic influence in the pathogenesis of human and animal diseases. This is why Experimental and Toxicologic Pathology meets the urgent need for an interdisciplinary journal felt by a wide variety of experts in medicine and biology, including pathologists, toxicologists, biologists, physicians, veterinary surgeons, pharmacists, and pharmacologists working in academic, industrial or clinical institutions.