Imaging of Myocardial Ischemia-Reperfusion Injury Using Sodium [¹⁸F]Fluoride Positron Emission Tomography/Computed Tomography in Rats and Humans.

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS Molecular Imaging Pub Date : 2017-01-01 DOI:10.1177/1536012117704767

Hongyoon Choi, Jeong Hee Han, Sue Yeon Lim, Inki Lee, Young-Seok Cho, Eun Ju Chun, Won Woo Lee

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引用次数: 6

Abstract

Positron emission tomography (PET)/computed tomography (CT) using sodium [¹⁸F]fluoride (Na[¹⁸F]F) has been proven to be a promising hot-spot imaging modality for myocardial infarction (MI). We investigated Na[¹⁸F]F uptake in ischemia-reperfusion injury (IRI) of rats and humans. Sodium [¹⁸F]fluoride PET/CT was performed in Sprague-Dawley rats that had IRI surgery, and it readily demonstrated prominent Na[¹⁸F]F uptake in the infarct area post-IRI. Sodium [¹⁸F]fluoride uptake was matched with negative 2,3,5-triphenyl-2 H-tetrazolium chloride staining results, accompanied by myocardial apoptosis and associated with positive calcium staining results. Furthermore, area at risk was negative for Na[¹⁸F]F uptake. Cyclosporine A (CysA) treatment reduced standardized uptake value of ¹⁸F over the infarct area, and a significant decrease in infarct size was also observed by the CysA treatment. In humans, Na[¹⁸F]F PET/CT readily demonstrated increased Na[¹⁸F]F uptake in the 2 patients with MI post-percutaneous coronary intervention. In conclusion, this study sheds light on the potential utility of Na[¹⁸F]F PET/CT as a hot-spot imaging modality for myocardial IRI.

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氟化钠[18F]正电子发射断层扫描/计算机断层扫描对大鼠和人心肌缺血再灌注损伤的成像

使用氟化钠(Na[18F]F)的正电子发射断层扫描(PET)/计算机断层扫描(CT)已被证明是一种有前途的心肌梗死(MI)热点成像方式。我们研究了Na[18F]F在大鼠和人缺血再灌注损伤(IRI)中的摄取情况。对接受IRI手术的Sprague-Dawley大鼠进行氟化钠[18F] PET/CT检查，很容易发现IRI后梗死区域有明显的钠[18F]F摄取。钠[18F]氟摄取与2,3,5-三苯基-2 h -四氮氯化铵阴性染色结果相匹配，伴有心肌凋亡，并与钙阳性染色结果相关。此外，危险区域Na[18F]F摄取呈阴性。环孢素A (CysA)治疗降低了梗死区域18F的标准摄取值，并且CysA治疗也观察到梗死面积显着减小。在人类中，2例心肌梗死患者经皮冠状动脉介入治疗后，Na[18F]F PET/CT迅速显示Na[18F]F摄取增加。总之，本研究揭示了Na[18F]F PET/CT作为心肌IRI热点成像方式的潜在用途。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

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3.60%

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期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.