Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential.

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS Molecular Imaging Pub Date : 2017-01-01 DOI:10.1177/1536012117708722
Lulu Wang, Amyn A Habib, Akiva Mintz, King C Li, Dawen Zhao
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引用次数: 15

Abstract

Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. However, this PS asymmetry is found disruptive in many tumor vascular endothelial cells. We discuss the underlying mechanisms for PS asymmetry maintenance in normal cells and its loss in tumor cells. The specificity of PS exposure in tumor vasculature but not normal blood vessels may establish it a useful biomarker for cancer molecular imaging. Indeed, utilizing PS-targeting antibodies, multiple imaging probes have been developed and multimodal imaging data have shown their high tumor-selective targeting in various cancers. There is a critical need for improved diagnosis and therapy for brain tumors. We have recently established PS-targeted nanoplatforms, aiming to enhance delivery of imaging contrast agents across the blood-brain barrier to facilitate imaging of brain tumors. Advantages of using the nanodelivery system, in particular, lipid-based nanocarriers, are discussed here. We also describe our recent research interest in developing PS-targeted nanotheranostics for potential image-guided drug delivery to treat brain tumors.

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以磷脂酰丝氨酸为靶点的脑肿瘤纳米治疗剂及其治疗潜力。
磷脂酰丝氨酸(PS)是细胞膜中含量最多的阴离子磷脂,在正常细胞中严格局限于内小叶。然而,这种PS不对称在许多肿瘤血管内皮细胞中被发现具有破坏性。我们讨论了正常细胞中PS不对称维持及其在肿瘤细胞中的丧失的潜在机制。PS暴露于肿瘤血管而非正常血管的特异性可能使其成为癌症分子成像的有用生物标志物。事实上,利用ps靶向抗体,多种成像探针已经开发出来,多模态成像数据显示它们在各种癌症中具有高肿瘤选择性靶向性。目前迫切需要改进脑肿瘤的诊断和治疗。我们最近建立了ps靶向纳米平台,旨在增强成像造影剂通过血脑屏障的传递,以促进脑肿瘤的成像。本文讨论了使用纳米递送系统,特别是脂基纳米载体的优点。我们还描述了我们最近的研究兴趣,即开发ps靶向纳米治疗技术,用于潜在的图像引导药物输送,以治疗脑肿瘤。
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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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