Anti-arthritic potential of marine macroalgae Turbinaria ornata in Complete Freund’s Adjuvant induced rats

Q2 Medicine Experimental and Toxicologic Pathology Pub Date : 2017-10-02 DOI:10.1016/j.etp.2017.06.006

S. Ananthi , V. Gayathri , R. Malarvizhi , Meenakshi Bhardwaj , Hannah R. Vasanthi

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引用次数: 18

Abstract

T. ornata a macroalgae rich in bioactive molecules possess various biological activities. Herein, the aim of the study is to evaluate the aqueous extract and the sulphated polysaccharide isolated from T. ornata for its anti-arthritic potential in Complete Freund’s Adjuvant (CFA) induced arthritis in rats. Anti-arthritic potential of aqueous T. ornata (ATO) and T. ornata sulphated polysaccharide (TSP) was evidenced by the significant reduction in paw volume and arthritic score. Inflammatory and antioxidant markers were found to be restored in the drug treated groups which was found to be in line with dexamethasone a standard anti-inflammatory drug. The histopathological and radiological examination adds on the support to the above findings confirming the anti-arthritic potential of ATO and TSP. It is interesting to note that the sulphated polysaccharide inhibits inflammation and bone damage at very low dose itself. Hence, TSP could be considered as a better candidate in the management of chronic inflammatory diseases like rheumatoid arthritis.

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大藻对完全弗氏佐剂诱导大鼠的抗关节炎作用

紫藻是一种富含生物活性分子的大型藻类，具有多种生物活性。本研究的目的是评价水提物和硫多糖对完全弗氏佐剂(CFA)诱导的大鼠关节炎的抗关节炎作用。水鸟蹄草(ATO)和鸟蹄草硫酸多糖(TSP)的抗关节炎作用可以通过显著减少足跖体积和关节炎评分来证明。治疗组炎症和抗氧化指标恢复，与标准抗炎药地塞米松一致。组织病理学和放射学检查进一步证实了ATO和TSP的抗关节炎作用。有趣的是，硫酸盐多糖本身在非常低的剂量下就能抑制炎症和骨损伤。因此，TSP可以被认为是治疗慢性炎症性疾病(如类风湿关节炎)的更好候选药物。

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来源期刊

Experimental and Toxicologic Pathology 医学-病理学

CiteScore

2.08

自引率

0.00%

发文量

审稿时长

5.3 weeks

期刊介绍： Cessation. The international multidisciplinary journal is devoted to the publication of studies covering the whole range of experimental research on disease processes and toxicology including cell biological investigations. Its aim is to support progress in the interdisciplinary cooperation of researchers working in pathobiology, toxicology, and cell biology independent of the methods applied. During the past decades increasing attention has been paid to the importance of toxic influence in the pathogenesis of human and animal diseases. This is why Experimental and Toxicologic Pathology meets the urgent need for an interdisciplinary journal felt by a wide variety of experts in medicine and biology, including pathologists, toxicologists, biologists, physicians, veterinary surgeons, pharmacists, and pharmacologists working in academic, industrial or clinical institutions.