{"title":"Systematic review on dental caries preventive and managing strategies among type 2 diabetic patients.","authors":"Haoran Chen, Robert Hill, Aylin Baysan","doi":"10.3389/froh.2022.998171","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this systematic review was to evaluate current evidence to prevent and manage dental caries in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the Participants, Intervention, Comparison, Outcomes and Study Design (PICOS) strategy was used to formulate a structured search: systematic search of PubMed, Cochrane Library, MEDLINE <i>via</i> Ovid, EMBASE, Scopus, Web of Science, and Lilacs without any date limit and/or language restrictions. Two independent reviewers performed data extraction and risk of bias assessments in the included studies. Data homogeneity was assessed according to interventions for treating dental caries in T2DM. Statistical analyses were performed with JMP<sup>®</sup>.</p><p><strong>Results: </strong>Two studies out of 909 were included in the systematic review. Only quantitative studies involving topical applications for management of dental caries in patients with T2DM were included. One study assessed the effect of intensive oral hygiene care program including toothbrushing and interdental cleaning using interproximal brushes and/or dental floss and supragingival debridement by dental hygienist with educational brochures in T2DM, while another investigated the immunologically active salivary substitutes with using Oral Hygiene Instructions (OHI), mouthwash, and moisturizing gel for 6 months. Intensive oral hygiene care program or immunologically active salivary substitutes with using OHI, mouthwash, and moisturizing gel for 6 months were reported to reverse/arrest dental caries in patients with T2DM.</p><p><strong>Conclusion: </strong>The current randomized controlled clinical trials demonstrated that regular extensive oral health education using interdental cleaning aids, mouthwash, moistening gel, and saliva substitutes including lactoperoxidase, lysozyme, glucose oxidase, and lactoferrin could control oral inflammation and contribute to the management of dental caries in patients with T2DM.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020197507, identifier: CRD42020197507.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"998171"},"PeriodicalIF":0.0000,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716193/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Oral Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/froh.2022.998171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Purpose: The purpose of this systematic review was to evaluate current evidence to prevent and manage dental caries in patients with type 2 diabetes mellitus (T2DM).
Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the Participants, Intervention, Comparison, Outcomes and Study Design (PICOS) strategy was used to formulate a structured search: systematic search of PubMed, Cochrane Library, MEDLINE via Ovid, EMBASE, Scopus, Web of Science, and Lilacs without any date limit and/or language restrictions. Two independent reviewers performed data extraction and risk of bias assessments in the included studies. Data homogeneity was assessed according to interventions for treating dental caries in T2DM. Statistical analyses were performed with JMP®.
Results: Two studies out of 909 were included in the systematic review. Only quantitative studies involving topical applications for management of dental caries in patients with T2DM were included. One study assessed the effect of intensive oral hygiene care program including toothbrushing and interdental cleaning using interproximal brushes and/or dental floss and supragingival debridement by dental hygienist with educational brochures in T2DM, while another investigated the immunologically active salivary substitutes with using Oral Hygiene Instructions (OHI), mouthwash, and moisturizing gel for 6 months. Intensive oral hygiene care program or immunologically active salivary substitutes with using OHI, mouthwash, and moisturizing gel for 6 months were reported to reverse/arrest dental caries in patients with T2DM.
Conclusion: The current randomized controlled clinical trials demonstrated that regular extensive oral health education using interdental cleaning aids, mouthwash, moistening gel, and saliva substitutes including lactoperoxidase, lysozyme, glucose oxidase, and lactoferrin could control oral inflammation and contribute to the management of dental caries in patients with T2DM.
目的:本系统综述的目的是评估2型糖尿病(T2DM)患者预防和治疗龋齿的现有证据。方法:遵循系统评价和荟萃分析的首选报告项目(PRISMA)指南，采用参与者、干预、比较、结果和研究设计(PICOS)策略制定结构化搜索:通过Ovid、EMBASE、Scopus、Web of Science和Lilacs系统搜索PubMed、Cochrane Library、MEDLINE，没有任何日期限制和/或语言限制。两名独立审稿人对纳入的研究进行了数据提取和偏倚风险评估。根据治疗2型糖尿病患者龋齿的干预措施评估数据的同质性。采用JMP®进行统计学分析。结果:909项研究中有2项纳入系统评价。仅纳入了涉及局部应用于T2DM患者龋齿管理的定量研究。一项研究评估了强化口腔卫生保健计划的效果，包括刷牙和使用近端牙刷和/或牙线进行牙间清洁，以及由牙科保健师使用T2DM教育手册进行龈上清创术，而另一项研究则使用口腔卫生指南(OHI)、漱口水和保湿凝胶进行了为期6个月的免疫活性唾液替代品调查。强化口腔卫生保健计划或免疫活性唾液替代品，使用OHI、漱口水和保湿凝胶6个月，据报道可以逆转/阻止T2DM患者的龋齿。结论:目前的随机对照临床试验表明，定期进行广泛的口腔健康教育，使用牙间清洁辅助工具、漱口水、保湿凝胶和唾液替代品(包括乳酸过氧化物酶、溶菌酶、葡萄糖氧化酶和乳铁蛋白)可以控制口腔炎症，有助于T2DM患者龋齿的管理。系统评价注册:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020197507，标识符:CRD42020197507。
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