Multifunctional System for Observing, Measuring and Analyzing Stimulation-Evoked Neurochemical Signaling.

... IEEE International Symposium on Medical Measurements and Applications : proceedings. IEEE International Symposium on Medical Measurements and Applications Pub Date : 2017-05-01 Epub Date: 2017-07-20 DOI:10.1109/MeMeA.2017.7985901

Christopher J Kimble, Joshua B Boesche, Diane R Eaker, Kenneth R Kressin, James K Trevathan, Seungleal Paek, Anders J Asp, Malcolm B McIntosh, J Luis Lujan

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引用次数: 1

Abstract

The ability to measure neurotransmitter activity using implanted electrochemical sensors offers researchers a potent technique for analyzing neural activity across specific neural circuitry. We have developed a wirelessly controlled device, WINCS Harmoni, to observe and measure neurotransmitter dynamics at up to four separate sensors, with high temporal and spatial resolution. WINCS Harmoni also incorporates a versatile neurostimulator that can be synchronized with electrochemical recording. The WINCS Harmoni platform is thus optimally suited for probing the neurochemical effects of neurostimulation, and may in turn enable the development of personalized therapies for multiple brain disorders.

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观察、测量和分析刺激诱发的神经化学信号的多功能系统。

利用植入式电化学传感器测量神经递质活动的能力为研究人员提供了一种分析特定神经回路中神经活动的有效技术。我们开发了一种无线控制设备，WINCS Harmoni，可以在多达四个独立的传感器上观察和测量神经递质动力学，具有高时间和空间分辨率。WINCS Harmoni还集成了一个多功能的神经刺激器，可以与电化学记录同步。因此，WINCS Harmoni平台非常适合探测神经刺激的神经化学效应，并可能反过来促进多种脑部疾病的个性化治疗的发展。

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... IEEE International Symposium on Medical Measurements and Applications : proceedings. IEEE International Symposium on Medical Measurements and Applications

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