Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults.

Q2 Medicine Current Gerontology and Geriatrics Research Pub Date : 2017-01-01 Epub Date: 2017-10-03 DOI:10.1155/2017/4218756
Huijin Lau, Arimi Fitri Mat Ludin, Nor Fadilah Rajab, Suzana Shahar
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引用次数: 27

Abstract

The increase of ageing population has raised public attention on the concept of successful ageing. Studies have shown that vitamin D, telomere length, and brain-derived neurotrophic factor (BDNF) have been associated with cognitive function. Therefore, this study aimed to identify neuroprotective factors for cognitive decline in different ageing groups. A total of 300 older adults aged 60 years and above were recruited in this population based cross-sectional study. Participants were categorized into three groups: mild cognitive impairment (MCI) (n = 100), usual ageing (UA) (n = 100), and successful ageing (SA) (n = 100). Dietary vitamin D intake was assessed through Diet History Questionnaire (DHQ). Out of the 300 participants, only 150 were subjected to fasting blood sample collection. These samples were used for serum vitamin D and plasma BDNF measurements. Whole blood telomere length was measured using RT-PCR method. The results show that the reduction of the risk of MCI was achieved by higher serum vitamin D level (OR: 0.96, 95% CI: 0.92-0.99, p < 0.05), higher plasma BDNF level (OR: 0.51, 95% CI: 0.30-0.88,  p < 0.05), and longer telomere (OR: 0.97, 95% CI: 0.95-0.99,  p < 0.001). In conclusion, participants with higher vitamin D level, higher BDNF level, and longer telomere length were more likely to age successfully.

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识别与马来西亚老年人成功老龄化和认知障碍风险相关的神经保护因素。
随着老龄化人口的增加,成功老龄化的概念引起了公众的关注。研究表明,维生素D、端粒长度和脑源性神经营养因子(BDNF)与认知功能有关。因此,本研究旨在确定不同年龄组认知能力下降的神经保护因素。在这项以人口为基础的横断面研究中,总共招募了300名60岁及以上的老年人。参与者被分为三组:轻度认知障碍(MCI) (n = 100),正常衰老(UA) (n = 100)和成功衰老(SA) (n = 100)。通过饮食史问卷(DHQ)评估膳食维生素D摄入量。在300名参与者中,只有150人接受了空腹血样采集。这些样品用于血清维生素D和血浆BDNF的测量。采用RT-PCR法测定全血端粒长度。结果显示,提高血清维生素D水平(OR: 0.96, 95% CI: 0.92-0.99, p < 0.05)、提高血浆BDNF水平(OR: 0.51, 95% CI: 0.30-0.88, p < 0.05)和延长端粒(OR: 0.97, 95% CI: 0.95-0.99, p < 0.001)可以降低MCI的风险。总之,维生素D水平较高、BDNF水平较高、端粒长度较长的参与者更有可能成功衰老。
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来源期刊
Current Gerontology and Geriatrics Research
Current Gerontology and Geriatrics Research Medicine-Geriatrics and Gerontology
CiteScore
5.20
自引率
0.00%
发文量
1
审稿时长
13 weeks
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