Estimation of the Basic Reproduction Number of Novel Influenza A (H1N1) pdm09 in Elementary Schools Using the SIR Model.

Abstract

Background: The novel influenza A (H1N1) pdm09 (A/H1N1pdm) pandemic of 2009-2010 had a great impact on society.

Objective: We analyzed data from the absentee survey, conducted in elementary schools of Oita City, to evaluate the A/H1N1pdm pandemic and to estimate the basic reproductive number (R₀ ) of this novel strain.

Method: We summarized the overall absentee data and calculated the cumulative infection rate. Then, we classified the data into 3 groups according to school size: small (<300 students), medium (300-600 students), and large (>600 students). Last, we estimated the R₀ value by using the Susceptible-Infected-Recovered (SIR) mathematical model.

Results: Data from 60 schools and 27,403 students were analyzed. The overall cumulative infection rate was 44.4%. There were no significant differences among the grades, but the cumulative infection rate increased as the school size increased, being 37.7%, 44.4%, and 46.6% in the small, medium, and large school groups, respectively. The optimal R₀ value was 1.33, comparable with that previously reported. The data from the absentee survey were reliable, with no missing values. Hence, the R₀ derived from the SIR model closely reflected the observed R₀ . The findings support previous reports that school children are most susceptible to A/H1N1pdm virus infection and suggest that the scale of an outbreak is associated with the size of the school.

Conclusion: Our results provide further information about the A/H1N1pdm pandemic. We propose that an absentee survey should be implemented in the early stages of an epidemic, to prevent a pandemic.