Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer.

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS Molecular Imaging Pub Date : 2017-01-01 DOI:10.1177/1536012117722911

Jun He, Leping Yang, Wenjun Yi, Wentao Fan, Yu Wen, Xiongying Miao, Li Xiong

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Abstract

Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional medical imaging modalities, such as its safety, effectiveness, and suitability for real-time imaging in the operating room. Recent advancements in contrast agents and intraoperative fluorescence imaging devices have led to a greater potential for intraoperative fluorescence imaging in clinical applications. Photodynamic therapy (PDT) is an alternative modality to treat tumors, which uses a light-sensitive drug (photosensitizers) and special light to destroy the targeted tissues. In this review, we discuss the fluorescent contrast agents, some newly developed imaging devices, and the successful clinical application of FGS. Additionally, we present the combined strategy of FGS with PDT to further improve the therapeutic effect for patients with cancer. Taken together, this review provides a unique perspective and summarization of FGS.

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荧光引导手术与光动力疗法相结合治疗癌症。

手术过程中需要对身体部位进行特定的可视化。荧光引导手术（FGS）使用荧光造影剂进行体内肿瘤成像，以检测和识别恶性和正常组织。与其他传统医学成像方式相比，荧光引导手术具有多种优势和临床益处，如安全、有效、适合手术室实时成像等。造影剂和术中荧光成像设备的最新进展为术中荧光成像的临床应用带来了更大的潜力。光动力疗法（PDT）是治疗肿瘤的另一种方法，它使用光敏药物（光敏剂）和特殊光线来破坏靶组织。在这篇综述中，我们将讨论荧光造影剂、一些新开发的成像设备以及 FGS 的成功临床应用。此外，我们还介绍了荧光造影剂与光动力疗法的结合策略，以进一步提高对癌症患者的治疗效果。总之，这篇综述为 FGS 提供了一个独特的视角和总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

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3.60%

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期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.