Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei-Infected Mice.

IF 2 Q3 PHARMACOLOGY & PHARMACY Drug Target Insights Pub Date : 2017-08-28 eCollection Date: 2017-01-01 DOI:10.1177/1177392817728725
Olayinka O Otegbade, Johnson A Ojo, Dolapo I Adefokun, Oyindamola O Abiodun, Bolaji N Thomas, Olusola Ojurongbe
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Abstract

This work explores the antiplasmodial potential of ethanol extract of Blighia sapida (Lin. Sapindaceae) in chloroquine (CQ)-resistant Plasmodium berghei (ANKA strain)-infected mice. Chloroquine-resistant (ANKA) strain of P berghei was inoculated intraperitoneally into Swiss albino mice. Mice were treated orally for 4 consecutive days, before and after inoculation (prophylactic, suppressive, and curative models) with graded doses of the plant extracts with Artemether-Lumefantrine (Coartem) as control. Prophylactically, the extract showed a remarkable activity in the chemosuppression of P berghei parasites (P < .01) ranging from 57% to 36.5% at doses of 200 to 800 mg/kg, respectively, whereas Coartem (10 mg/kg) produced 62.1% chemosuppression. No significant chemosuppression was observed in the curative and suppressive models. The plant extract appeared to be safe at the highest dose tested (5000 mg/kg) for acute toxicity, with no adverse effect on the different organs. The plant extract possesses prophylactic antimalarial activity, which supports its use in the prevention of malaria.

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树皮乙醇提取物对实验性疟原虫感染小鼠有显著的预防作用
本研究探讨了无患子(Blighia sapida)乙醇提取物对氯喹(CQ)抗性疟原虫(ANKA 株)感染小鼠的抗疟潜力。将耐氯喹(ANKA 株)疟原虫腹腔接种到瑞士白化小鼠体内。小鼠在接种前后连续 4 天口服不同剂量的植物提取物进行治疗(预防、抑制和治疗模型),并以蒿甲醚-本芴醇(Coartem)作为对照。在预防性治疗中,萃取物对伯格希氏疟原虫的化学抑制显示出显著的活性(P
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来源期刊
Drug Target Insights
Drug Target Insights PHARMACOLOGY & PHARMACY-
CiteScore
2.70
自引率
0.00%
发文量
5
审稿时长
8 weeks
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