The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2017-09-01 Epub Date: 2017-07-27 DOI:10.1007/s40778-017-0085-5
Negar Seyedhassantehrani, Takayoshi Otsuka, Shambhavi Singh, David M Gardiner
{"title":"The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche.","authors":"Negar Seyedhassantehrani, Takayoshi Otsuka, Shambhavi Singh, David M Gardiner","doi":"10.1007/s40778-017-0085-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Recent advances in genomics and gene editing have expanded the range of model organisms to include those with interesting biological capabilities such as regeneration. Among these are the classic models of regeneration biology, the salamander. Although stimulating endogenous regeneration in humans likely is many years away, with advances in stem cell biology and biomedical engineering (e.g. bio-inspired materials), it is evident that there is great potential to enhance regenerative outcomes by approaching the problem from an engineering perspective. The question at this point is what do we need to engineer?</p><p><strong>Recent findings: </strong>The value of regeneration models is that they show us how regeneration works, which then can guide efforts to mimic these developmental processes therapeutically. Among these models, the Accessory Limb Model (ALM) was developed in the axolotl as a gain-of-function assay for the sequential steps that are required for successful regeneration. To date, this model has identified a number of proregenerative signals, including growth factor signaling associated with nerves, and signals associated with the extracellular matrix (ECM) that induce pattern formation.</p><p><strong>Summary: </strong>Identification of these signals through the use of models in highly regenerative vertebrates (e.g. the axolotl) offers a wide range of possible modifications for engineering bio-inspired, biomimetic materials to create a dynamic stem cell niche for regeneration and scar-free repair.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"3 3","pages":"156-163"},"PeriodicalIF":2.3000,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722022/pdf/nihms895878.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Stem Cell Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40778-017-0085-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/7/27 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose of review: Recent advances in genomics and gene editing have expanded the range of model organisms to include those with interesting biological capabilities such as regeneration. Among these are the classic models of regeneration biology, the salamander. Although stimulating endogenous regeneration in humans likely is many years away, with advances in stem cell biology and biomedical engineering (e.g. bio-inspired materials), it is evident that there is great potential to enhance regenerative outcomes by approaching the problem from an engineering perspective. The question at this point is what do we need to engineer?

Recent findings: The value of regeneration models is that they show us how regeneration works, which then can guide efforts to mimic these developmental processes therapeutically. Among these models, the Accessory Limb Model (ALM) was developed in the axolotl as a gain-of-function assay for the sequential steps that are required for successful regeneration. To date, this model has identified a number of proregenerative signals, including growth factor signaling associated with nerves, and signals associated with the extracellular matrix (ECM) that induce pattern formation.

Summary: Identification of these signals through the use of models in highly regenerative vertebrates (e.g. the axolotl) offers a wide range of possible modifications for engineering bio-inspired, biomimetic materials to create a dynamic stem cell niche for regeneration and scar-free repair.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
将轴足类肢体再生模型作为干细胞利基工程的探索工具。
综述的目的:基因组学和基因编辑的最新进展扩大了模式生物的范围,使其包括那些具有再生等有趣生物学能力的生物。其中包括再生生物学的经典模型--蝾螈。虽然刺激人类的内源性再生可能还需要很多年,但随着干细胞生物学和生物医学工程学(如生物启发材料)的进步,从工程学的角度来解决这个问题,显然有很大的潜力来提高再生效果。目前的问题是,我们需要设计什么?再生模型的价值在于它们向我们展示了再生是如何进行的,从而指导我们努力模仿这些发育过程进行治疗。在这些模型中,辅助肢体模型(ALM)是在腋肢中开发的,作为成功再生所需的连续步骤的功能增益试验。总结:通过使用高度再生脊椎动物(如腋毛蜥)的模型来识别这些信号,为工程生物启发、生物仿生材料提供了广泛的可能修改,以创建一个动态干细胞龛,促进再生和无疤痕修复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Current Stem Cell Reports
Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
0.00%
发文量
19
期刊介绍: The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
期刊最新文献
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives Machine Learning Approaches for Stem Cells Transcription factors and splice factors - interconnected regulators of stem cell differentiation.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1