The Disease-Modifying Effects of Hyaluronan in the Osteoarthritic Disease State.

IF 1.9 Q2 ORTHOPEDICS Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2017-08-11 eCollection Date: 2017-01-01 DOI:10.1177/1179544117723611

Mathew A Nicholls, Anke Fierlinger, Faizan Niazi, Mohit Bhandari

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引用次数: 41

Abstract

Hyaluronic acid (HA) has been a treatment modality for patients with knee osteoarthritis (OA) for many years now. Since HA was first introduced for the treatment of painful knee OA, much has been elucidated regarding both the etiology of this disease and the mechanisms by which HA may mitigate joint pain and tissue destruction. The objectives of this article are to (1) describe the etiology and pathophysiology of OA including both what is known about the genetics and biochemistry, (2) describe the role of HA on disease progression, (3) detail the antinociceptive and anti-inflammatory actions of HA in OA, and (4) present evidence of disease-modifying effects of HA in the preservation and restoration of the extracellular matrix. These data support that HA is not only just a simple device used for viscosupplementation but also a biologically active molecule that can affect the physiology of articular cartilage.

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透明质酸在骨关节炎疾病状态中的疾病调节作用。

透明质酸(HA)多年来一直是膝骨关节炎(OA)患者的一种治疗方式。自从透明质酸首次被引入治疗疼痛性膝关节炎以来，关于这种疾病的病因和透明质酸减轻关节疼痛和组织破坏的机制已经有了很多阐明。本文的目的是:(1)描述OA的病因学和病理生理学，包括已知的遗传学和生物化学，(2)描述HA在疾病进展中的作用，(3)详细描述HA在OA中的抗伤性和抗炎作用，(4)提供HA在保存和恢复细胞外基质中的疾病改善作用的证据。这些数据表明，透明质酸不仅是一种简单的增粘装置，而且是一种生物活性分子，可以影响关节软骨的生理机能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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