{"title":"Haem-Based Sensors of O<sub>2</sub>: Lessons and Perspectives.","authors":"Eduardo H S Sousa, Marie-Alda Gilles-Gonzalez","doi":"10.1016/bs.ampbs.2017.05.001","DOIUrl":null,"url":null,"abstract":"<p><p>Haem-based sensors have emerged during the last 15 years as being a large family of proteins that occur in all kingdoms of life. These sensors are responsible mainly for detecting binding of O<sub>2</sub>, CO and NO and reporting the ligation status to an output domain with an enzymatic or macromolecule-binding property. A myriad of biological functions have been associated with these sensors, which are involved in vasodilation, bacterial symbiosis, chemotaxis and biofilm formation, among others. Here, we critically review several bacterial systems for O<sub>2</sub> sensing that are extensively studied in many respects, focusing on the lessons that are important to advance the field.</p>","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ampbs.2017.05.001","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Microbial Physiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.ampbs.2017.05.001","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/7/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 13
Abstract
Haem-based sensors have emerged during the last 15 years as being a large family of proteins that occur in all kingdoms of life. These sensors are responsible mainly for detecting binding of O2, CO and NO and reporting the ligation status to an output domain with an enzymatic or macromolecule-binding property. A myriad of biological functions have been associated with these sensors, which are involved in vasodilation, bacterial symbiosis, chemotaxis and biofilm formation, among others. Here, we critically review several bacterial systems for O2 sensing that are extensively studied in many respects, focusing on the lessons that are important to advance the field.
期刊介绍：
Advances in Microbial Physiology publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, the editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to traditional views of whole cell physiology.
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