Transcriptional Regulation of Stem Cell and Cancer Stem Cell Metabolism.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2017-03-01 Epub Date: 2017-01-21 DOI:10.1007/s40778-017-0071-y

Ahmet Alptekin, Bingwei Ye, Han-Fei Ding

{"title":"Transcriptional Regulation of Stem Cell and Cancer Stem Cell Metabolism.","authors":"Ahmet Alptekin, Bingwei Ye, Han-Fei Ding","doi":"10.1007/s40778-017-0071-y","DOIUrl":null,"url":null,"abstract":"Purpose of review: Metabolism is increasingly recognized as a major player in control of stem cell function and fate. How stem cell metabolism is established, maintained, and regulated is a fundamental question of biology and medicine. In this review, we discuss major metabolic programs in stem cells and cancer stem cells, with a focus on key transcription factors that shape the stem cell metabolic phenotype.Recent findings: Cancer stem cells primarily use oxidative phosphorylation for energy generation, in contrast to normal stem cells, which rely on glycolytic metabolism with the exception of mouse embryonic stem cells. Transcription factors control the metabolic phenotype of stem cells by modulating the expression of enzymes and thus the activity of metabolic pathways. It is evident that HIF1α and PGC1α function as master regulators of glycolytic and mitochondrial metabolism, respectively.Summary: Transcriptional regulation is a key mechanism for establishing specific metabolic programs in stem cells and cancer stem cells.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"3 1","pages":"19-27"},"PeriodicalIF":2.3000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-017-0071-y","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Stem Cell Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40778-017-0071-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/21 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}

引用次数: 12

Abstract

Purpose of review: Metabolism is increasingly recognized as a major player in control of stem cell function and fate. How stem cell metabolism is established, maintained, and regulated is a fundamental question of biology and medicine. In this review, we discuss major metabolic programs in stem cells and cancer stem cells, with a focus on key transcription factors that shape the stem cell metabolic phenotype.

Recent findings: Cancer stem cells primarily use oxidative phosphorylation for energy generation, in contrast to normal stem cells, which rely on glycolytic metabolism with the exception of mouse embryonic stem cells. Transcription factors control the metabolic phenotype of stem cells by modulating the expression of enzymes and thus the activity of metabolic pathways. It is evident that HIF1α and PGC1α function as master regulators of glycolytic and mitochondrial metabolism, respectively.

Summary: Transcriptional regulation is a key mechanism for establishing specific metabolic programs in stem cells and cancer stem cells.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

干细胞和肿瘤干细胞代谢的转录调控。

综述目的:代谢越来越被认为是控制干细胞功能和命运的重要因素。干细胞代谢是如何建立、维持和调节的，是生物学和医学的一个基本问题。在这篇综述中，我们讨论了干细胞和癌症干细胞的主要代谢程序，重点是塑造干细胞代谢表型的关键转录因子。最近的研究发现:癌症干细胞主要利用氧化磷酸化来产生能量，而正常干细胞依赖糖酵解代谢(小鼠胚胎干细胞除外)。转录因子通过调节酶的表达和代谢途径的活性来控制干细胞的代谢表型。很明显，HIF1α和PGC1α分别是糖酵解和线粒体代谢的主要调节因子。摘要:转录调控是干细胞和肿瘤干细胞建立特定代谢程序的关键机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.