Nucleoside-O-Methyl-(H)-Phosphinates: Novel Monomers for the Synthesis of Methylphosphonate Oligonucleotides Using H-Phosphonate Chemistry

Ondřej Kostov, Ondřej Páv, Ivan Rosenberg
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引用次数: 1

Abstract

This unit comprises the straightforward synthesis of protected 2′-deoxyribonucleoside-O-methyl-(H)-phosphinates in both 3′- and 5′-series. These compounds represent a new class of monomers compatible with the solid-phase synthesis of oligonucleotides using H-phosphonate chemistry and are suitable for the preparation of both 3′- and 5′-O-methylphosphonate oligonucleotides. The synthesis of 4-toluenesulfonyloxymethyl-(H)-phosphinic acid as a new reagent for the preparation of O-methyl-(H)-phosphinic acid derivatives is described. © 2017 by John Wiley & Sons, Inc.

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核苷- o -甲基-(H)-膦酸盐:用H-膦酸盐化学合成甲基膦酸寡核苷酸的新单体
该单元包括3 '和5 '系列的受保护的2 ' -脱氧核糖核苷- o -甲基-(H)-膦酸盐的直接合成。这些化合物代表了一类与h -膦酸盐固相合成寡核苷酸兼容的新单体,适用于制备3 ' -和5 ' - o -甲基膦酸寡核苷酸。介绍了4-甲苯磺酰氧基甲基-(H)-膦酸的合成,作为制备邻甲基-(H)-膦酸衍生物的新试剂。©2017 by John Wiley &儿子,Inc。
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Current Protocols in Nucleic Acid Chemistry
Current Protocols in Nucleic Acid Chemistry Chemistry-Organic Chemistry
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期刊介绍: Published in association with International Society for Nucleosides, Nucleotides & Nucleic Acids (IS3NA) , Current Protocols in Nucleic Acid Chemistry is equally valuable for biotech, pharmaceutical, and academic labs. It is the resource for designing and running successful research projects in the rapidly growing and changing field of nucleic acid, nucleotide, and nucleoside research.
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