Serum Uric Acid Is Associated with Poor Outcome in Black Africans in the Acute Phase of Stroke.

IF 1.8 Q3 PERIPHERAL VASCULAR DISEASE Stroke Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-09-10 DOI:10.1155/2017/1935136

Yacouba N Mapoure, Chia Mark Ayeah, M S Doualla, H Ba, Hugo B Mbatchou Ngahane, Salomon Mbahe, Henry N Luma

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引用次数: 15

Abstract

Background: Prognostic significance of serum uric acid (SUA) in acute stroke still remains controversial.

Objectives: To determine the prevalence of hyperuricemia and its association with outcome of stroke patients in the Douala General Hospital (DGH).

Methods: This was a hospital based prospective cohort study which included acute stroke patients with baseline SUA levels and 3-month poststroke follow-up data. Associations between high SUA levels and stroke outcomes were analyzed using multiple logistic regression and survival analysis (Cox regression and Kaplan-Meier).

Results: A total of 701 acute stroke patients were included and the prevalence of hyperuricemia was 46.6% with a mean SUA level of 68.625 ± 24 mg/l. Elevated SUA after stroke was associated with death (OR = 2.067; 95% CI: 1.449-2.950; p < 0.001) but did not predict this issue. However, an independent association between increasing SUA concentration and mortality was noted in a Cox proportional hazards regression model (adjusted HR = 1.740; 95% CI: 1.305-2.320; p < 0.001). Furthermore, hyperuricemia was an independent predictor of poor functional outcome within 3 months after stroke (OR = 2.482; 95% CI: 1.399-4.404; p = 0.002).

Conclusion: The prevalence of hyperuricemia in black African stroke patients is quite high and still remains a predictor of poor outcome.

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非洲黑人中风急性期血清尿酸与预后不良相关

背景:血清尿酸(SUA)在急性脑卒中中的预后意义仍有争议。目的:了解杜阿拉总医院(DGH)脑卒中患者高尿酸血症的患病率及其与预后的关系。方法:这是一项基于医院的前瞻性队列研究，包括基线SUA水平的急性卒中患者和卒中后3个月的随访数据。使用多重逻辑回归和生存分析(Cox回归和Kaplan-Meier)分析高SUA水平与卒中结局之间的关系。结果:共纳入701例急性脑卒中患者，高尿酸血症发生率为46.6%，平均SUA水平为68.625±24 mg/l。卒中后SUA升高与死亡相关(OR = 2.067;95% ci: 1.449-2.950;P < 0.001)，但不能预测这个问题。然而，在Cox比例风险回归模型中，SUA浓度升高与死亡率之间存在独立关联(调整后的HR = 1.740;95% ci: 1.305-2.320;P < 0.001)。此外，高尿酸血症是卒中后3个月内功能预后不良的独立预测因子(OR = 2.482;95% ci: 1.399-4.404;P = 0.002)。结论:非洲黑人卒中患者高尿酸血症的患病率相当高，仍然是预后不良的预测因素。

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