The Effects of Vitamin D Supplementation in Newly Diagnosed Type 1 Diabetes Patients: Systematic Review of Randomized Controlled Trials.

Q3 Medicine Review of Diabetic Studies Pub Date : 2017-06-01 Epub Date: 2017-10-10 DOI:10.1900/RDS.2017.14.260

Elina Gregoriou, Ioannis Mamais, Irene Tzanetakou, Giagkos Lavranos, Stavri Chrysostomou

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引用次数: 39

Abstract

Aim: The aim of this study was to examine the effects of vitamin D supplementation in patients newly diagnosed with type 1 diabetes (T1D) assessed by insulin needs and changes in glycemic indices, as evidenced by randomized controlled trials (RCTs).

Methods: A total of 7 RCTs were retrieved from PubMed/Medline and EBSCO databases by MeSH term search, and were reviewed systematically. The RCTs included examined the effects of alphacalcidole (n = 2), cholecalciferol (n = 2), and calcitriol (n = 3) supplementation on changes in daily insulin dose (DID), fasting Cpeptide (FCP), stimulated C-peptide (SCP), and HbA1c. In total, 287 individuals, diagnosed with T1D within a period of 4 weeks to 1 year and aged between 5 to 38 years, were examined.

Results: Significant positive effects on DID, FCP, and SCP levels were observed after supplementation with alphacalcidole and cholecalciferol, whereas supplementation with calcitriol showed no effect.

Conclusions: Vitamin D supplementation in the form of alphacalcidole and cholecalciferol appears to be beneficial in the treatment of T1D patients by attenuating the natural history of the disease.

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补充维生素D对新诊断的1型糖尿病患者的影响:随机对照试验的系统评价

目的:本研究的目的是研究补充维生素D对新诊断为1型糖尿病(T1D)的患者的影响，通过胰岛素需求和血糖指数的变化来评估，随机对照试验(RCTs)证明了这一点。方法:采用MeSH检索方法从PubMed/Medline和EBSCO数据库中检索7篇随机对照试验，并对其进行系统回顾。这些随机对照试验包括检测补充α骨化醇(n = 2)、胆骨化醇(n = 2)和骨化三醇(n = 3)对每日胰岛素剂量(DID)、空腹肽(FCP)、刺激c肽(SCP)和HbA1c变化的影响。总共有287人在4周到1年内被诊断为T1D，年龄在5到38岁之间。结果:补充α骨化醇和胆骨化醇后，对DID、FCP和SCP水平有显著的积极影响，而补充骨化三醇则无影响。结论:维生素D以α骨化醇和胆骨化醇的形式补充似乎有利于T1D患者的治疗，可以减轻疾病的自然史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Review of Diabetic Studies Medicine-Internal Medicine

CiteScore

1.80

自引率

0.00%

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期刊介绍： The Review of Diabetic Studies (RDS) is the society"s peer-reviewed journal published quarterly. The purpose of The RDS is to support and encourage research in biomedical diabetes-related science including areas such as endocrinology, immunology, epidemiology, genetics, cell-based research, developmental research, bioengineering and disease management.