Effect of the Ginger Derivative, 6-Shogaol, on Ferritin Levels in Patients With Low to Intermediate-1-Risk Myelodysplastic Syndrome-A Small, Investigative Study.

IF 3 Q2 Medicine Clinical Medicine Insights-Blood Disorders Pub Date : 2017-11-02 eCollection Date: 2017-01-01 DOI:10.1177/1179545X17738755
Terry Golombick, Terrence H Diamond, Arumugam Manoharan, Rajeev Ramakrishna, Vladimir Badmaev
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引用次数: 4

Abstract

Background: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal stem cell disorders characterized by dysplastic and ineffective hematopoiesis and peripheral cytopenias. Elevated serum ferritin (SF) is often observed in nontransfused, lower risk MDS. It has been reported that ineffective erythropoiesis enhances iron absorption in MDS through downregulation of hepcidin and its prohormones such that SF rises.

Aim: To determine the effect of 6-shogaol, a dehydration derivative of ginger, known to have hepatoprotective and chemotherapeutic activity, on 6 early-stage, transfusion-independent patients with MDS, 3 of whom had raised levels of SF.

Method: Six patients with MDS with low or intermediate-1 subtypes, as defined by the International Prognostic Scoring System (IPSS), were recruited into the study and were administered 1 gel capsule daily containing 20 mg ginger extract standardized for 20% 6-shogaol. Blood and urine samples were collected and various markers monitored at regular intervals.

Results: 6-shogaol caused a decrease in SF levels in 3 of 6 patients with early MDS (50%) whose SF levels were elevated at the start of the study. Our findings suggest upregulation of hepcidin and its prohormones, possibly through an improvement in liver function.

Discussion: In light of the encouraging results in this small, investigative study, we are planning a larger study to confirm the beneficial effect of 6-shogaol in patients with raised ferritin levels due to ineffective erythropoiesis.

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姜衍生物6-Shogaol对低至中危骨髓增生异常综合征患者铁蛋白水平的影响——一项小型调查研究
背景:骨髓增生异常综合征(MDS)是一种异质性克隆干细胞疾病,其特征是造血功能异常和外周血细胞减少。血清铁蛋白(SF)升高是经常观察到在非输血,低风险MDS。据报道,无效的红细胞生成通过下调hepcidin及其前激素,使SF升高,从而增强MDS的铁吸收。目的:确定6-shogaol(生姜的脱水衍生物,已知具有肝保护和化疗活性)对6例早期不依赖输血的MDS患者的影响,其中3例患者SF水平升高。方法:招募6例国际预后评分系统(IPSS)定义的低或中1亚型MDS患者,每天给予1粒凝胶胶囊,含有20 mg标准化的6-shogaol。收集血液和尿液样本,并定期监测各种标志物。结果:6-shogaol导致6例早期MDS患者中3例(50%)SF水平下降,这些患者在研究开始时SF水平升高。我们的研究结果表明,hepcidin及其原激素的上调可能通过改善肝功能。讨论:鉴于这项小型调查研究的令人鼓舞的结果,我们正在计划进行一项更大规模的研究,以确认6-shogaol对因红细胞生成无效而导致铁蛋白水平升高的患者的有益作用。
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审稿时长
8 weeks
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