Exploring the activities of ruthenium nanomaterials as reactive oxygen species scavengers.

Abstract

Research on noble metal nanoparticles (NPs) able to scavenge reactive oxygen species (ROS) has undergone a tremendous growth recently. However, the interactions between ruthenium nanoparticles (Ru NPs) and ROS have never been systematically explored thus far. This research focused on the decomposition of hydrogen peroxide (H₂O₂), scavenging of hydroxyl radicals (^•OH), superoxide radical (O₂^•-), singlet oxygen (¹O₂), 2,2'-azino-bis(3-ethylbenzenothiazoline- 6-sulfonic acid ion (ABTS^•+), and 1,1-diphenyl-2-picrylhydrazyl radical (^•DPPH) in the presence of commercial Ru NPs using the electron spin resonance technique. In vitro cell studies demonstrated that Ru NPs have excellent biocompatibility and exert a cytoprotective effect against oxidative stress. These findings may spark fresh enthusiasm for the applications of Ru NPs under relevant physiologically conditions.