{"title":"News From the Heart Natriuretic System.","authors":"Ines Armando","doi":"10.1161/CIRCGENETICS.117.002011","DOIUrl":null,"url":null,"abstract":"Renal and nonrenal mechanisms are involved in the long-term regulation of blood pressure that is dependent on a precise balance among humoral agents and vasoconstrictor and vasodilator hormones and other factors that act to increase or decrease renal sodium transport. These imply a complex interaction between natriuretic and antinatriuretic systems. The dysregulation of ion transport intrinsic and extrinsic to the kidney has been proposed to cause essential hypertension.\n\nSee Article by Salo et al \n\nAn important natriuretic system is that comprising the cardiac hormones, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP), playing a critical role in the reduction of blood pressure and cardiac disorders with relevance to renal and cardiovascular homeostasis. ANP is synthesized and stored in the atrial granules as a prohormone with 126 amino acids, proANP. BNP is deglycosylated from a 108-amino acid prohormone, proBNP, and further processed into an amino …","PeriodicalId":10277,"journal":{"name":"Circulation: Cardiovascular Genetics","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/CIRCGENETICS.117.002011","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Circulation: Cardiovascular Genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1161/CIRCGENETICS.117.002011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Renal and nonrenal mechanisms are involved in the long-term regulation of blood pressure that is dependent on a precise balance among humoral agents and vasoconstrictor and vasodilator hormones and other factors that act to increase or decrease renal sodium transport. These imply a complex interaction between natriuretic and antinatriuretic systems. The dysregulation of ion transport intrinsic and extrinsic to the kidney has been proposed to cause essential hypertension.
See Article by Salo et al
An important natriuretic system is that comprising the cardiac hormones, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP), playing a critical role in the reduction of blood pressure and cardiac disorders with relevance to renal and cardiovascular homeostasis. ANP is synthesized and stored in the atrial granules as a prohormone with 126 amino acids, proANP. BNP is deglycosylated from a 108-amino acid prohormone, proBNP, and further processed into an amino …
期刊介绍：
Circulation: Genomic and Precision Medicine considers all types of original research articles, including studies conducted in human subjects, laboratory animals, in vitro, and in silico. Articles may include investigations of: clinical genetics as applied to the diagnosis and management of monogenic or oligogenic cardiovascular disorders; the molecular basis of complex cardiovascular disorders, including genome-wide association studies, exome and genome sequencing-based association studies, coding variant association studies, genetic linkage studies, epigenomics, transcriptomics, proteomics, metabolomics, and metagenomics; integration of electronic health record data or patient-generated data with any of the aforementioned approaches, including phenome-wide association studies, or with environmental or lifestyle factors; pharmacogenomics; regulation of gene expression; gene therapy and therapeutic genomic editing; systems biology approaches to the diagnosis and management of cardiovascular disorders; novel methods to perform any of the aforementioned studies; and novel applications of precision medicine. Above all, we seek studies with relevance to human cardiovascular biology and disease.
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