{"title":"Antibodies to <i>β</i><sub>1</sub> integrins inhibit dendritic growth in rat sympathetic neurons.","authors":"Pamela Lein, Dennis Higgins","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We have examined the role of integrins in the development of dendrites in embryonic rat sympathetic neurons <i>in vitro</i>. Previous studies have established that exposure to a basement membrane extract (BME) causes these neurons to form dendrites (Lein and Higgins, 1989). The current experiments demonstrate that the dendrite-promoting activity of BME can be markedly inhibited by antibodies directed against the <i>β</i><sub>1</sub> integrin subunit. Although the specific ∝ integrin sub-unit(s) that mediate the effect of BME on dendritic growth were not identified, it was found that neither the ∝<sub>1</sub>, or ∝<sub>4</sub> sub-units, nor RGD-binding integrins were involved to any significant extent. These data suggest that, in addition to their well established role in regulating axonal growth, <i>β</i><sub>1</sub> integrins also participate in dendritic growth.</p>","PeriodicalId":55361,"journal":{"name":"Biomedical Research-India","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724964/pdf/nihms844547.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Research-India","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
We have examined the role of integrins in the development of dendrites in embryonic rat sympathetic neurons in vitro. Previous studies have established that exposure to a basement membrane extract (BME) causes these neurons to form dendrites (Lein and Higgins, 1989). The current experiments demonstrate that the dendrite-promoting activity of BME can be markedly inhibited by antibodies directed against the β1 integrin subunit. Although the specific ∝ integrin sub-unit(s) that mediate the effect of BME on dendritic growth were not identified, it was found that neither the ∝1, or ∝4 sub-units, nor RGD-binding integrins were involved to any significant extent. These data suggest that, in addition to their well established role in regulating axonal growth, β1 integrins also participate in dendritic growth.
期刊介绍：
Biomedical Research is an interdisci¬plinary Research Journal for publication of original research work in all major disciplines of Basic and Clinical Medical Sciences. Invited and submitted review articles on current topics will also be included. Doctors are encouraged to contribute interesting case reports. The objective of the journal is to provide a scientific communication medium to discuss the utmost advancements in the domain of biomedical sciences. This journal aims to assemble and reserve precise, specific, detailed data on this immensely important subject. Biomedical Research is a scientific open access journal that specifies and describes the development activities conducted in the field of biomedicine research. This journal encompasses the study related to microbiology, biochemistry, clinical, medical, computational and engineering aspects relevant to biomedical sciences. Articles will be also considered from related analysis from cell biology, developmental biology, genetics, computational studies, biophysics, immunology, translational medicine biomedical research, biomedicine, biomedical science, biomedical engineering, biology, biomedical informatics, biomedical diagnostics, biomedical ethics, biomedical therapy, biomedical systems, biomedical technology, medical research, clinical research, physiology, pharmacology, biochemistry, personalized medicine, surgical instrument disciplines. Submission of important articles containing advanced research output aiding in forwarding the subject are most welcome. The wide scope of the journal will aid in contributing a great measure of scientific information related to the advances in towards better healthcare.
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