T I Nevidimova, E I Masterova, D N Savochkina, N A Bokhan
{"title":"Cytokine mediated changes of pain sensitivity in predisposition to substance dependence.","authors":"T I Nevidimova, E I Masterova, D N Savochkina, N A Bokhan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The purpose of study was evaluation of extra and intracellular cytokine production in blood cultures and cytokine-pain relationship at different stages od addiction.</p><p><strong>Methods: </strong>Classic and multiplex enzyme immunoassay, flow, cytometry, algometry, visual analogue scale were used in 34 abusers, 12 users and 20 control subjects.</p><p><strong>Results: </strong>Cytokine profile correlated with clinical parameters and pain sensitivity in abusers (mostly IL-6 and IL-1β). IL-10 production is increased in episodic and systematic users. Activation of intracellular IL-6 synthesis was found in users. Both parameters are expected to affect the emotional evaluation of pain.</p><p><strong>Conclusion: </strong>To assess the predisposition to substance dependence most informative are balance of extra and intracellular production of IL-6 and IL-10 and algometry.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 3","pages":"57-60"},"PeriodicalIF":0.0000,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The purpose of study was evaluation of extra and intracellular cytokine production in blood cultures and cytokine-pain relationship at different stages od addiction.
Methods: Classic and multiplex enzyme immunoassay, flow, cytometry, algometry, visual analogue scale were used in 34 abusers, 12 users and 20 control subjects.
Results: Cytokine profile correlated with clinical parameters and pain sensitivity in abusers (mostly IL-6 and IL-1β). IL-10 production is increased in episodic and systematic users. Activation of intracellular IL-6 synthesis was found in users. Both parameters are expected to affect the emotional evaluation of pain.
Conclusion: To assess the predisposition to substance dependence most informative are balance of extra and intracellular production of IL-6 and IL-10 and algometry.
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