Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?

IF 1.9 Q2 ORTHOPEDICS Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders Pub Date : 2018-01-08 eCollection Date: 2018-01-01 DOI:10.1177/1179544117751627
Amal Akassou, Youssef Bakri
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引用次数: 32

Abstract

The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Although the diagnostic and prognostic roles of HLA-B27 in AS are still debated, there is an increasing interest for HLA-B27-based effects especially in HLA-B27(+) patients with AS. This review will focus in the examination of published reports regarding the influence of HLA-B27 status on the demographic and clinical features in AS, with specific interest to its role on AS severity.

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HLA-B27状态是否影响强直性脊柱炎表型?
HLA-B27与强直性脊柱炎(AS)的关联仍然是一个有趣的模型,可能存在于分子和医学上的人类疾病之间。虽然早在1973年就有报道,但它对AS和相关脊柱炎的影响仍然是科学界面临的主要挑战。了解其致病机制及其在这些疾病中的作用具有重要意义。尽管HLA-B27在AS中的诊断和预后作用仍有争议,但对基于HLA-B27的效应的兴趣越来越大,特别是在HLA-B27(+) AS患者中。本综述将重点研究已发表的关于HLA-B27状态对AS人口统计学和临床特征影响的报告,并对其在AS严重程度中的作用特别感兴趣。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
14
审稿时长
8 weeks
期刊最新文献
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