Links and risks associated with psoriasis and metabolic syndrome.

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2015-11-02 eCollection Date: 2015-01-01 DOI:10.2147/PTT.S54089
Aikaterini I Liakou, Christos C Zouboulis
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引用次数: 11

Abstract

Introduction: Psoriasis has long been considered a systemic inflammatory disease. Lately, it has been strongly associated with obesity, as well as other components of metabolic syndrome, such as dyslipidemia, insulin resistance, and arterial hypertension.

Methods: We reviewed the literature of the last decade by using the keywords: psoriasis, metabolic syndrome, and/or obesity in PubMed and Medline.

Results: Obesity and psoriasis seem to share similar profiles of systemic inflammation. Serum cytokines such as TNF-α, CRP, IL-6, and IL-12 are elevated in both disorders. The more severely an individual is affected with psoriasis, the more likely it is to be obese. This makes the disease an important health care issue, which requires the cooperation of dermatologists with other medical specialists.

Discussion: This review attempts to summarize the links and risks that associate psoriasis with obesity, and highlight the concerns and queries for both disorders in the future.

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牛皮癣和代谢综合征的联系和风险。
银屑病长期以来被认为是一种全身性炎症性疾病。最近,它与肥胖以及代谢综合征的其他组成部分,如血脂异常、胰岛素抵抗和动脉高血压密切相关。方法:我们以PubMed和Medline上的关键词:牛皮癣、代谢综合征和/或肥胖,回顾了近十年的文献。结果:肥胖和牛皮癣似乎有相似的全身性炎症。血清细胞因子如TNF-α、CRP、IL-6和IL-12在两种疾病中均升高。一个人患牛皮癣越严重,就越有可能肥胖。这使得这种疾病成为一个重要的卫生保健问题,这需要皮肤科医生与其他医学专家的合作。讨论:本综述试图总结牛皮癣与肥胖之间的联系和风险,并强调未来对这两种疾病的关注和疑问。
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