The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-03-13 DOI:10.1007/s40778-018-0114-z

Denis G Alferez, Bruno M Simões, Sacha J Howell, Robert B Clarke

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Abstract

Purpose of review: This review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a hierarchical organization in tumors where at its apex lies a subpopulation of cancer cells endowed with self-renewal and differentiation capacity.

Recent findings: In breast cancer (BC), CSCs have been suggested to play a key role in tumor maintenance, disease progression, and the formation of metastases. In preclinical models of BC, only a few CSCs are required sustain tumor re-growth, especially after conventional anti-endocrine treatments. CSCs include therapy-resistant clones that survive standard of care treatments like chemotherapy, irradiation, and hormonal therapy.

Summary: The relevance of hormones for both normal mammary gland and BC development is well described, but it was only recently that the activities of hormones on CSCs have been investigated, opening new directions for future BC treatments and CSCs.

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类固醇激素在乳腺中的作用及其对癌症干细胞的影响

综述的目的：本综述将讨论类固醇激素、雌激素和孕酮以及针对类固醇受体的治疗方法如何调节癌症干细胞（CSC）的活性。CSC理论提出了肿瘤中的分层组织，其顶点是具有自我更新和分化能力的癌细胞亚群：在乳腺癌（BC）中，癌细胞干细胞被认为在肿瘤的维持、疾病进展和转移的形成中起着关键作用。在乳腺癌的临床前模型中，只有少数细胞间充质干细胞能维持肿瘤的再生长，尤其是在常规抗内分泌治疗后。CSCs包括耐药克隆，它们能在化疗、照射和激素治疗等标准治疗方法中存活下来。摘要：激素与正常乳腺和BC发育的相关性已被充分描述，但直到最近才有人研究了激素对CSCs的活性，这为未来BC治疗和CSCs开辟了新方向。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

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期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.