[Could the cytokines concentration be a marker of IBD activity and be useful in evaluation of IBD differentiation?]

Przeglad lekarski Pub Date : 2016-01-01

Irena Cieċko-Michalska, Iga Wierzbicka-Tutka, Malgorzata Szczepanek, Danuta Fedak, Tomasz Mach

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Abstract

Background: In inflammatory bowel disease (IBD) the imbalance between cytokines pro- and antinflammatory is observed. The aim of this study was the assessment of interleukin-10 (IL-10), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentration usefulness in the evaluation of the activity of ulcerative colitis (UC) and Cohn’s disease (CD).

Methods: 35 patients diagnosed with UC and 39 with CD were examined. The control group (CG) consisted of 35 healthy volunteers. Diagnosis of the disease was confirmed by videocolonoscopy and histopathological evaluation of intestinal biopsies. Disease activity of UC was assessed according to the Mayo Scoring System and by the Crohn Disease Activiti Index (CDAI) in CD patients. Among patients with UC 18 (51%) had severe, 14 (40%) moderate and 3 (9%) mild disease. Among patients with CD 7 (18%) was diagnosed with high, 27 (69%) moderate, and 5 (13%) with low activity of the disease. WBC, PLT, serum concentration of TNF-α, IL-6 i IL-10 were determined.

Results: The average concentration of TNF-α in UC patients was: 14.3 (IQR=12.6), in CD: 12.6 (IQR=11.9), in the CG: 3.1 (IQR=1.7). The average concentration of IL-6 in UC was: 19.6 (IQR=21), in CD: 10.8 (IQR=7.6), in CG : 3.2 (IQR=1.6). The average concentration of IL-10 in UC was: 14.4 (IQR=5.9), in CD: 10.4 (IQR=9.3), in the CG: 3.3 (IQR=2.5). In the IBD TNF-α, IL-6 and IL-10 concentration was significantly higher than in CG. However, IL-10 was significantly higher in UC than CD. In patients with UC statistically significant positive correlation between the concentration of TNF-α, IL-6 and IL-10 and disease activity was noticed. There were no correlation between TNF-α, IL-6 and IL-10 concentration and CD activity.

Conclusion: Determination of TNF-α, IL-6 and IL-10 serum concentration can be used for noninvasive evaluation of inflammation activity in patients with IBD. IL-10 concentration may be helpful in differentiation of UC and CD.

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细胞因子浓度是否可以作为IBD活性的标志，并可用于IBD分化的评估?］

背景:在炎症性肠病(IBD)中，促炎因子和抗炎因子之间存在不平衡。本研究的目的是评估白细胞介素-10 (IL-10)、白细胞介素-6 (IL-6)和肿瘤坏死因子-α (TNF-α)浓度在评估溃疡性结肠炎(UC)和科恩病(CD)活动性中的作用。方法:对35例诊断为UC的患者和39例诊断为CD的患者进行检查。对照组(CG)由35名健康志愿者组成。经内镜检查和肠活检组织病理学检查证实。根据Mayo评分系统和CD患者的克罗恩病活动性指数(CDAI)评估UC的疾病活动性。在UC 18患者中(51%)有严重疾病，14(40%)有中度疾病，3(9%)有轻度疾病。在cd7患者中，有18%被诊断为高活动性，27人(69%)被诊断为中度活动性，5人(13%)被诊断为低活动性。测定WBC、PLT、血清TNF-α、IL-6、IL-10浓度。结果:UC患者TNF-α平均浓度为:14.3(IQR=12.6)， CD患者为:12.6 (IQR=11.9)， CG患者为:3.1 (IQR=1.7)。UC中IL-6的平均浓度为:19.6(IQR=21)， CD中为:10.8 (IQR=7.6)， CG中为:3.2 (IQR=1.6)。UC组IL-10平均浓度为:14.4 (IQR=5.9)， CD组为:10.4 (IQR=9.3)， CG组为:3.3(IQR=2.5)。IBD组TNF-α、IL-6、il -10浓度明显高于CG组。UC患者IL-10明显高于CD患者。住院UC患者TNF-α、IL-6、IL-10浓度与疾病活动度有统计学意义的正相关。TNF-α、IL-6、IL-10浓度与cd活性无相关性。结论:血清tnf -α、IL-6、IL-10浓度测定可用于IBD患者炎症活动性的无创评价。IL-10浓度可能有助于UC和CD的分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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