Relative Risk Chart Score for the Assessment of the Cardiovascular Risk in Young Patients with Ankylosing Spondylitis.

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2018-02-15 eCollection Date: 2018-01-01 DOI:10.1155/2018/1847894
Javier Rueda-Gotor, Fernanda Genre, Alfonso Corrales, Ricardo Blanco, Patricia Fuentevilla, Virginia Portilla, Rosa Expósito, Cristina Mata Arnaiz, Trinitario Pina, Carlos González-Juanatey, Luis Rodriguez-Rodriguez, Miguel A González-Gay
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引用次数: 4

Abstract

Objective: To determine if the use of the relative risk (RR) chart score may help to identify young ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease.

Methods: 73 AS patients younger than 50 years were assessed. CV risk was calculated according to the total cholesterol systematic coronary risk evaluation (TC-SCORE) and the RR chart score. C-reactive protein (CRP) value at disease diagnosis and carotid ultrasound data were also analyzed.

Results: Twenty (27.4%) patients exhibited carotid plaques being classified into the category of very high CV risk. None of them was found to have a high/very high TC-SCORE. CRP > 3 mg/L at disease diagnosis was associated with the presence of carotid plaques (odds ratio 5.66, p = 0.03). Whereas only 5 (14.2%) of the 35 patients with RR = 1 had carotid plaques, 15 (39.5%) of 38 with RR > 1 showed plaques. A model that included the performance of carotid US in patients with RR > 1 who had CRP > 3 mg/L allowed us to identify 60% of very high risk patients, with a specificity of 77.4%.

Conclusions: RR chart score assessment may help to identify young AS patients at high risk of CV disease.

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评价年轻强直性脊柱炎患者心血管风险的相对风险图评分。
目的:确定相对危险度(RR)量表评分是否有助于识别具有心血管(CV)疾病高风险的年轻强直性脊柱炎(AS)患者。方法:对73例年龄小于50岁的AS患者进行评估。根据总胆固醇系统冠状动脉风险评价(TC-SCORE)和RR图评分计算CV风险。分析c反应蛋白(CRP)在疾病诊断中的价值及颈动脉超声资料。结果:20例(27.4%)患者的颈动脉斑块被归类为非常高心血管风险。没有发现他们有高/非常高的TC-SCORE。疾病诊断时CRP > 3 mg/L与颈动脉斑块的存在相关(优势比5.66,p = 0.03)。RR = 1的35例患者中只有5例(14.2%)出现颈动脉斑块,而RR > 1的38例患者中有15例(39.5%)出现斑块。一个包括RR > 1且CRP > 3 mg/L的患者颈动脉US表现的模型使我们能够识别60%的高危患者,特异性为77.4%。结论:RR表评分评估有助于识别心血管疾病高风险的年轻AS患者。
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CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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