Effect of Olanzapine on Clinical and Polysomnography Profiles in Patients with Schizophrenia.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2018-02-20 eCollection Date: 2018-01-01 DOI:10.1155/2018/3968015
Mohammad Zia Ul Haq Katshu, Sukanto Sarkar, S Haque Nizamie
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引用次数: 7

Abstract

Acute and short-term administration of olanzapine has a favorable effect on sleep in schizophrenia patients. This study aimed to clarify the effect of olanzapine on polysomnographic profiles of schizophrenia patients during the acute phase of illness after controlling for previous drug exposure. Twenty-five drug-naïve or drug-free schizophrenia patients were assessed at baseline and after six weeks of olanzapine treatment on Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), and Udvalg for Kliniske Undersogelser (UKU) side-effect rating scale and a whole-night polysomnography; fifteen patients completed the study. There was a significant reduction in all psychopathological variables with maximum reduction in PANSS total, BPRS total, and PANSS positive scores. A significant increase in total sleep time (TST), sleep efficiency (SE), nonrapid eye movement (NREM) stage 1 duration, stage 3 duration, stage 4 duration, and stage 4 percentage of TST, number of rapid eye movement (REM) periods, REM duration, and REM percentage of TST was observed. REM latency at baseline inversely predicted the reduction in BPRS total and PANSS total and positive scores. In summary, short-term treatment with olanzapine produced significant improvement in clinical and polysomnography profiles of patients with schizophrenia with shorter REM latency predicting a good clinical response.

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奥氮平对精神分裂症患者临床及多导睡眠图的影响。
急性和短期给予奥氮平对精神分裂症患者的睡眠有良好的影响。本研究旨在阐明奥氮平在控制既往药物暴露后对精神分裂症患者急性期多导睡眠图的影响。25例drug-naïve或无药物精神分裂症患者在基线和奥氮平治疗6周后进行简短精神病学评定量表(BPRS)、阳性和阴性综合征量表(PANSS)、Udvalg for Kliniske Undersogelser (UKU)副作用评定量表和通宵多导睡眠仪评估;15名患者完成了这项研究。所有精神病理变量均显著降低,其中PANSS总分、BPRS总分和PANSS阳性评分降幅最大。总睡眠时间(TST)、睡眠效率(SE)、非快速眼动(NREM)第1阶段持续时间、第3阶段持续时间、第4阶段持续时间、第4阶段TST百分比、快速眼动(REM)周期数、REM持续时间和快速眼动(REM)百分比均显著增加。基线时的REM潜伏期与BPRS总分和PANSS总分及阳性评分的下降呈负相关。综上所述,奥氮平短期治疗显著改善了精神分裂症患者的临床和多导睡眠图特征,这些患者的快速眼动潜伏期较短,预示着良好的临床反应。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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