Regioselective synthesis of pyridines by redox alkylation of pyridine N-oxides with malonates.

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2017-11-28 DOI:10.1007/s00706-017-2081-y
Miran Lemmerer, Christopher J Teskey, Daniel Kaiser, Nuno Maulide
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Abstract

Abstract: A regioselective synthesis of pyridines by the addition of malonate anions to pyridine N-oxide derivatives, which have been activated by trifluoromethanesulfonic anhydride, is reported. The reaction selectively affords either 2- or 4-substituted pyridines in good yields.

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通过吡啶 N-氧化物与丙二酸盐的氧化还原烷基化作用,实现吡啶的区域选择性合成。
摘要:报告了一种通过丙二酸根阴离子与吡啶 N-氧化物衍生物的加成反应对吡啶进行区域选择性合成的方法,该衍生物已被三氟甲磺酸酐活化。该反应以良好的产率选择性地得到 2-或 4-取代的吡啶:
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来源期刊
Monatshefte Fur Chemie
Monatshefte Fur Chemie 化学-化学综合
CiteScore
3.70
自引率
5.60%
发文量
116
审稿时长
3.3 months
期刊介绍: "Monatshefte für Chemie/Chemical Monthly" was originally conceived as an Austrian journal of chemistry. It has evolved into an international journal covering all branches of chemistry. Featuring the most recent advances in research in analytical chemistry, biochemistry, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, Chemical Monthly publishes refereed original papers and a section entitled "Short Communications". Reviews, symposia in print, and issues devoted to special fields will also be considered.
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