Mandible protraction alters Type I collagen, osteocalcin and osteonectin gene expression in adult mice condyle.

Annali di stomatologia Pub Date : 2018-03-08 eCollection Date: 2017-09-01 DOI:10.11138/ads/2017.8.3.095

Patricia Valerio, Filipi Perfeito, Livia P Moura, Deborah N Ribeiro, Simone O A Fernandes, Almir S Martins, Maria F Leite

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引用次数: 3

Abstract

Mandible condyle remodeling is a great challenge on craniofacial growth studies. The great majority of the reports deals with growing period. However, there is a great necessity to clarify the importance of functional stimulation on adult mandible condyle remodeling. By using an adult mouse model, we investigated the influence of mandible forwarding on condyle remodeling and gene expression by bone forming cells. Tomographic and scintigraphic evaluations showed sagittal growth and cell activity enhancement. RT-PCR showed that Type I collagen, osteocalcin and osteonectin expression level can be altered. We showed that functional stimulation is necessary to maintain the regular gene expression by condyle bone forming cells in adult mice. It opens new frame for further investigations aiming new clinical approaches to temporomandibular joint problems treatment, as well as mandible retrusion treatment.

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下颌骨牵伸改变成年小鼠髁突I型胶原蛋白、骨钙素和骨连接素基因表达。

下颌骨髁突重塑是颅面生长研究的一大挑战。绝大多数报告都是关于生长期的。然而，有必要明确功能刺激在成人下颌骨髁重构中的重要性。采用成年小鼠模型，研究下颌骨前移对骨形成细胞对髁突重塑及基因表达的影响。断层扫描和扫描显示矢状面生长和细胞活性增强。RT-PCR结果显示，I型胶原、骨钙素和骨连接素的表达水平发生改变。我们发现功能刺激是维持成年小鼠髁骨形成细胞正常基因表达的必要条件。这为进一步研究颞下颌关节问题治疗和下颌骨后缩治疗的新临床方法开辟了新的框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annali di stomatologia

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