[Research progress and prospects of phosphorothioate modification - A review].

微生物学报 Pub Date : 2016-12-04
Yali Gao, Zixin Deng, Shi Chen
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Abstract

DNA phosphorothioate modification was the first reported physiological modification in the DNA backbone. Five putative proteins encoded by the five-member dndABCDE gene cluster replaced the non-bridging oxygen in the sugar-phosphate backbone with a sulfur. Phosphorothioate modification occurrs in sequence-selective and Rp stereo-specific manner in diverse bacterial stains. In recent years, researchers have made systemic achievements in this area. To have a comprehensive understanding of this unusual modification, we reviewed the discovery and research progress in DNA phosphorothioate modification and also discussed opportunities and challenges in the future.

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[硫代磷酸酯改性的研究进展与展望]。
DNA硫代修饰是首次报道的DNA主干的生理修饰。由五元dndABCDE基因簇编码的五个假定蛋白用一个硫取代了糖-磷酸主链中的非桥接氧。在不同的细菌染色中,硫代磷酸酯修饰以序列选择性和Rp立体特异性的方式发生。近年来,研究人员在这一领域取得了系统的成果。为了全面了解这种不寻常的修饰,我们回顾了DNA硫代修饰的发现和研究进展,并讨论了未来的机遇和挑战。
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期刊介绍: Acta Microbiologica Sinica(AMS) is a peer-reviewed monthly (one volume per year)international journal,founded in 1953.It covers a wide range of topics in the areas of general and applied microbiology.The journal publishes original papers,reviews in microbiological science,and short communications describing unusual observations. Acta Microbiologica Sinica has been indexed in Index Copernicus (IC),Chemical Abstract (CA),Excerpt Medica Database (EMBASE),AJ of Viniti (Russia),Biological Abstracts (BA),Chinese Science Citation Database (CSCD),China National Knowledge Infrastructure(CNKI),Institute of Scientific and Technical Information of China(ISTIC),Chinese Journal Citation Report(CJCR),Chinese Biological Abstracts,Chinese Pharmaceutical Abstracts,Chinese Medical Abstracts and Chinese Science Abstracts.
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