[Advances in Zika vaccines].

微生物学报 Pub Date : 2017-02-04
Ran Wang, Hui Chen, Jing An
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Abstract

Aedes (a genus of mosquitoes) transfers Zika virus (ZIKV) to humans. About two billion people worldwide live in ZIKV-affected areas. The outbreak of ZIKV in Central and South America threats public health worldwide, especially for pregnant women and their fetuses. ZIKV infection has become one of the major causes of neonatal congenital microcephaly and adult Guillain-Barre syndrome. No effective vaccine and treatment are available now against ZIKV infection. The first Zika vaccine is a DNA vaccine which affords complete protection against ZIKV and induces a high level of specific antibody titers. Advantages of DNA vaccines are simple to design and produce, safe for adults and fetuses, and without virulence recovery induced by reproducible vaccines. Some positive vaccines including traditional and emerging ones are in research and some progresses have been achieved. This article reviews the current situation and progress of Zika vaccines.

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[寨卡疫苗的进展]。
伊蚊(蚊子的一种)将寨卡病毒(ZIKV)传播给人类。全世界约有20亿人生活在寨卡病毒感染地区。寨卡病毒在中南美洲的暴发威胁着全世界的公共卫生,特别是孕妇及其胎儿。寨卡病毒感染已成为新生儿先天性小头畸形和成人格林-巴利综合征的主要病因之一。目前还没有针对寨卡病毒感染的有效疫苗和治疗方法。第一种寨卡病毒疫苗是一种DNA疫苗,可提供完全的寨卡病毒保护,并诱导高水平的特异性抗体滴度。DNA疫苗的优点是设计和生产简单,对成人和胎儿安全,并且没有可重复疫苗引起的毒力恢复。包括传统疫苗和新兴疫苗在内的一些阳性疫苗正在研究中,并取得了一些进展。本文综述了寨卡疫苗的研究现状和进展。
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期刊介绍: Acta Microbiologica Sinica(AMS) is a peer-reviewed monthly (one volume per year)international journal,founded in 1953.It covers a wide range of topics in the areas of general and applied microbiology.The journal publishes original papers,reviews in microbiological science,and short communications describing unusual observations. Acta Microbiologica Sinica has been indexed in Index Copernicus (IC),Chemical Abstract (CA),Excerpt Medica Database (EMBASE),AJ of Viniti (Russia),Biological Abstracts (BA),Chinese Science Citation Database (CSCD),China National Knowledge Infrastructure(CNKI),Institute of Scientific and Technical Information of China(ISTIC),Chinese Journal Citation Report(CJCR),Chinese Biological Abstracts,Chinese Pharmaceutical Abstracts,Chinese Medical Abstracts and Chinese Science Abstracts.
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