Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in their Infancy of being Connected.

Jagroop Dhaliwal, Laura Trinkle-Mulcahy, Diane C Lagace
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引用次数: 12

Abstract

Within the brain, the physiological and pathological functions of autophagy in development and throughout the lifespan are being elucidated. This review summarizes recent in vitro and in vivo results that are defining the role of autophagy-related genes during the process of adult neurogenesis. We also discuss the need for future experiments to determine the molecular mechanism and functional significance of autophagy in the different neural stem cell populations and throughout the stages of adult neurogenesis.

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自噬和成人神经发生:半个世纪前的发现,但还处于联系的初期。
在大脑中,自噬在发育和整个生命周期中的生理和病理功能正在被阐明。本文综述了近年来自噬相关基因在成人神经发生过程中的作用的体外和体内研究结果。我们还讨论了未来实验的必要性,以确定自噬在不同神经干细胞群体和整个成人神经发生阶段的分子机制和功能意义。
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