Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine.

4区医学 Q2 Biochemistry, Genetics and Molecular Biology Advances in experimental medicine and biology Pub Date : 2018-01-01 DOI:10.1007/5584_2018_215

Maryam Rahmati, Cristian Pablo Pennisi, Ali Mobasheri, Masoud Mozafari

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引用次数: 29

Abstract

Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.

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干细胞生物工程支架在组织工程和再生医学中的应用。

基于干细胞的治疗，利用干细胞再生受损或病变组织的能力，正在广泛考虑再生医学应用。然而，关于细胞持久性差和细胞移植植入的限制仍然存在。近年来，人们研究了几种生物材料来控制移植干细胞的命运，旨在提高其治疗效率。在本章中，我们重点介绍了其中一些生物材料的一般性质，包括聚合物、陶瓷和纳米生物材料。本章第一部分简要介绍了干细胞生物学、来源及其微环境。本章的第二部分介绍了一些最新的研究，研究了不同类型的生物材料和方法，旨在模拟干细胞微环境，以更精确地控制干细胞的命运。

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来源期刊

Advances in experimental medicine and biology 医学-医学：研究与实验

CiteScore

5.90

自引率

0.00%

发文量

465

审稿时长

2-4 weeks

期刊介绍： Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.