Non-alcoholic fatty liver disease: an update on diagnosis.

Clujul medical (1957) Pub Date : 2018-01-01 Epub Date: 2018-04-25 DOI:10.15386/cjmed-993

Dan L Dumitrascu, Manuela G Neuman

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引用次数: 40

Abstract

Background and aim: The non-alcoholic fatty liver disease (NAFLD) and its sub-entity, the non-alcoholic steatohepatitis (NASH) represent a field of a tremendous progress in recent years. Clinicians need to remain updated with new data on pathogenesis and therapy. The present mini review aims to present some new scientific reports on the diagnosis of NAFLD and NASH for clinical practitioners.

Methods: A systematic literature search of the main international databases was performed. We looked for seminal and innovative papers published in main international languages. A narrative review of the topic was consequently written.

Results: This review describes new data on the diagnosis of NAFLD including NASH. Liver punction biopsy remains the gold standard. However many patients and clinicians prefer to use noninvasive methods. We present the serological tests and the imaging methods used to diagnose inflammation and fibrosis occurring in NAFLD and NASH.

Conclusions: NAFLD-NASH are multifaceted entities that have to be diagnosed and treated by skilled and informed practitioners.

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非酒精性脂肪性肝病:最新诊断

背景与目的:非酒精性脂肪性肝病(NAFLD)及其亚实体非酒精性脂肪性肝炎(NASH)是近年来取得巨大进展的一个领域。临床医生需要不断更新有关发病机制和治疗的新数据。本综述旨在为临床医生提供一些关于NAFLD和NASH诊断的新科学报告。方法:对国际主要数据库进行系统的文献检索。我们寻找以主要国际语言发表的具有开创性和创新性的论文。因此编写了一份关于该专题的叙述性评论。结果:本综述描述了NAFLD包括NASH诊断的新数据。肝脏穿刺活检仍然是金标准。然而，许多患者和临床医生更喜欢使用非侵入性方法。我们介绍了用于诊断NAFLD和NASH中发生的炎症和纤维化的血清学测试和影像学方法。结论:NAFLD-NASH是多方面的，必须由熟练和知情的从业人员诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clujul medical (1957)

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