Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats.

IF 2.5 Q2 PERIPHERAL VASCULAR DISEASE International Journal of Vascular Medicine Pub Date : 2018-01-28 eCollection Date: 2018-01-01 DOI:10.1155/2018/6428630

Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes

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引用次数: 14

Abstract

Background: Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.

Method: 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n = 8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.

Results: NAC decreased (p < 0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p < 0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p < 0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM.

Conclusion: NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.

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n -乙酰半胱氨酸对stz诱导糖尿病大鼠血脂异常及碳水化合物代谢的影响。

背景:1型糖尿病(T1DM)的特点是胰岛素缺乏导致高血糖，这与糖尿病并发症如心血管疾病有关。抗氧化剂已被证明是糖尿病并发症的良好替代品，n -乙酰半胱氨酸(NAC)具有抗氧化特性。本研究旨在探讨NAC对链脲佐菌素(STZ-)诱导的糖尿病大鼠血脂及动脉粥样硬化指数(AI)的影响。方法:32只体重±250 g的60日龄雄性Wistar大鼠随机分为4组(n = 8): CTRL:对照组;CTRL+NAC: NAC处理的对照组大鼠;DM:糖尿病大鼠;DM+NAC: NAC治疗的糖尿病大鼠。STZ诱导T1DM (60 mg/kg, ip;NAC (25 mg/kg/d)灌胃，连续37 d。这些动物可以随意得到食物和水。实验结束后，采集血液和心脏组织样本，分析能量代谢、血脂和AI。结果:与DM相比，NAC降低了DM+NAC治疗组大鼠的血糖、能量摄入、碳水化合物和蛋白质消耗(p < 0.01)，提高了DM+NAC治疗组大鼠的消化效率(p < 0.01)。与DM组相比，NAC组DM+NAC组糖尿病大鼠血脂水平和AI水平明显降低(p < 0.01)。结论:NAC组改善stz诱导的糖尿病大鼠血脂水平，降低AI水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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