Change in Prolactin Levels in Pediatric Patients Given Antipsychotics for Schizophrenia and Schizophrenia Spectrum Disorders: A Network Meta-Analysis.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2018-04-01 eCollection Date: 2018-01-01 DOI:10.1155/2018/1543034
Chakrapani Balijepalli, Eric Druyts, Michael J Zoratti, Ping Wu, Salmaan Kanji, Kiran Rabheru, Kevin Yan, Kristian Thorlund
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引用次数: 11

Abstract

Background: Treatment of schizophrenia with first- and second-generation antipsychotics has been associated with elevated prolactin levels, which may increase the risk for prolactin-related adverse events.

Methods: Randomized controlled trials (RCTs) included in a recent systematic review were considered for this analysis. A Bayesian network meta-analysis was used to compare changes in prolactin levels in pediatric patients diagnosed with schizophrenia or schizophrenia spectrum disorders treated with second-generation antipsychotics (SGAs).

Results: Five RCTs, including 989 patients combined, have evaluated the changes in prolactin for pediatric patients after 6 weeks of treatment with risperidone, quetiapine, aripiprazole, olanzapine, and paliperidone. In the overall study population, treatment with risperidone was associated with the highest increase in mean prolactin levels compared to other SGAs. Patients treated with risperidone 4-6 mg/day were found to experience the greatest increases (55.06 ng/ml [95% CrI: 40.53-69.58]) in prolactin levels, followed by risperidone 1-3 mg/day, paliperidone 3-6 mg/day, and paliperidone 6-12 mg/day.

Conclusions: This study shows that there are differences in SGAs ability to cause hyperprolactinemia. Further, there is clear evidence of safety concerns with risperidone and paliperidone treatment in adolescent schizophrenia patients.

Registration: PROSPERO CRD42014009506.

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精神分裂症和精神分裂症谱系障碍患儿服用抗精神病药物后催乳素水平的变化:一项网络荟萃分析
背景:使用第一代和第二代抗精神病药物治疗精神分裂症与催乳素水平升高有关,这可能增加催乳素相关不良事件的风险。方法:随机对照试验(rct)纳入最近的系统评价纳入本分析。采用贝叶斯网络荟萃分析比较了经第二代抗精神病药物治疗的精神分裂症或精神分裂症谱系障碍儿童患者催乳素水平的变化。结果:5项随机对照试验,共989例患者,评估了利培酮、喹硫平、阿立哌唑、奥氮平和帕利哌酮治疗6周后儿科患者催乳素的变化。在整个研究人群中,与其他SGAs相比,利培酮治疗与平均催乳素水平的最高升高相关。利培酮4 ~ 6 mg/d组患者催乳素水平升高幅度最大(55.06 ng/ml [95% CrI: 40.53 ~ 69.58]),其次为利培酮1 ~ 3 mg/d、帕利培酮3 ~ 6 mg/d、帕利培酮6 ~ 12 mg/d。结论:本研究表明SGAs引起高泌乳素血症的能力存在差异。此外,有明确的证据表明,利培酮和帕利培酮治疗青少年精神分裂症患者存在安全性问题。注册号:PROSPERO CRD42014009506。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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